The Role And Mechanism Of Zhuanggu Tablets In Treatment Of Steroid-induced Avascular Necrosis

Avascular Necrosis of the Femoral Head (below brief name ANFH) is a common disease in osteopathy clinic xhich is difficult to be treated ,involving 20 millions people in the world. It's outbreak high peak at 40—50 years old, men and women comparison is roughly 4:1.Because of the factors ,such as the wound, medicine abuse, drinks to excess ,ANFH shows the rising trend year by year. In all factors,over-dose usage of hormone is one of the most important and frequent etiopathogenisis. ANFH could cause damage and collapse of femoral head in late stage ,which directly affect life quality of the patient.There is no record of"ANFH"in TCM,but ANFH belongs to the eategory of"gushi","gubi"and"guwei"in Chinese medicine.The name,pathology and symptom were stated in lingjiu·cijiezhenxielunpian: the evil of person is too deep in the body. Cold and hot mutually fight , which staying a long time is obvious .If cold wins hot, the bone is painful but the meat is withered.If hot wins its cold, lousy meat and putrefied muscle become nong.Then it injury bone. Internal injury bone is gushi. Past dynasties doctors have clarified this kind of disease a lot.It is the coincident cognition that the gas and blood can't run smoothly so that liver and kidney are damaged.Zhuanggu slice is clinical experience prescription. It aims directly at kidney faint and blood stasis and shows the apparent effects .There are restoring virility stronging bone and liver kidney -benifite herbs like Gusuibu , Xuejie,Buguzhi,Lurong ,Xuduan ,Zirantong and removing stasis blood herbs like Ruxiang and Moyao,et al.These two parts are matched each other to bring into full play of kidney -benifite and removing stasis blood.This thesis includes two part. The first part is a review on the research advances of ANFH and SANFH. The second part is original studies about the effect of Zhuanggu slice on SANFH.1 documents review It included"the development of etiological factor and pathological study in ANFH"and"the modern study development of Steroid-induced Avascular Necrosis of the Femoral Head (SANFH)". In this part,the development of tiological factor and pathological study in ANFH in Chinese medicine and western medicine and the modern study development on SANFHwere introduced.2 experimental study In this part,the effects of Zhuanggu slice were studied and results were as follows:2.1 the histopathology,measuiement and mechanics effect of Zhuanggu slice in SANFH rats boneSANFH rats, Zhuanggu slice can alleviate the histopathology changes of bone obviously, alleviate the cell death of bone, make normal bone cell quantity obvious to increase.It can...