The Oct Used In Nondestructive Testing Of Human Blood Glucose

Diabetes is a chronic disease that inflicts people's health all around the world. It is very important for the health of the diabetes patients to measure the glucose level frequently and routinely. There have been enormous efforts by many scientific groups to monitor glucose concentration non-invasively using different optical techniques. However, these techniques face limitations because of their low sensitivity and accuracy. Optical coherence tomography (OCT), has being applied for non-invasive tomography imaging of tissue with high resolution, making it easier for diagnosing some tenacious diseases like glaucoma, cancer, etc.. Comparing to other optical techniques, the high resolution and tomography imaging ability of OCT allow the exceptionally accurate measurement of the scattering properties for specific layer of tissue.In this article, I proposed a new method of measuring the concentration of glucose by detecting the changes of scattering coefficient of skin using OCT technique. The optical properties of tissue and the mechanism of glucose concentration induced changes of scattering coefficient are discussed. A phantom (Polysterene micro-sphere solution) is developed to simulate the optical properties of skin. Several experiments are carried out to test the feasibility of using our OCT system to detect the small changes of scattering coefficient in phantom solution. The experiment results show that our OCT system is able the detection as small as 0.5% change of refractive index of the solution. In-vivo OCT image of the human skin is obtained and analyzed, preparing for the future in-vivo study of human. The experimental results are discussed and future suggestions of researching are given out. Finally, it is concluded that OCT technique offers a new promising detection method for non-invasive glucose monitoring.