Research On Wearable Functional Probe For Non-invasive Blood Glucose Detection In OCT

In recent years,the incidence of diabetes and the population has been increasing,and traditional electrochemical blood glucose testing has the risk of being invasive and susceptible to infection.Optical non-invasive blood glucose detection technology has a good application prospect.Optical coherence tomography(OCT)is a real-time,non-contact,non-destructive high-resolution optical three-dimensional imaging technology.It has received extensive attention in the field of non-invasive blood glucose,but its detection results are easily affected by the detection object itself and external environmental factors,such as the temperature of the collection site,the location of the collection site,and the pressure it receives,improving the accuracy and stability of OCT blood glucose detection.Is the main research direction of OCT blood glucose detection.This article focuses on eliminating the effects of temperature,displacement,and pressure on the test results.The main tasks are:1.Taking the hardware improvement as the starting point,we designed a wearable probe that integrates a temperature control device,a displacement control device,and a pressure detection device.By controlling the high temperature of the collection site,it is ensured that the temperature fluctuation of the skin during the test is controlled within ± 0.3 ° C,and the influence of temperature on the test result can be controlled to ± 0.1mmol / l;the probe and the positioning label paper cooperate with each other,and the probe and The relative displacement of the collection site is controlled within 0.5mm,and the effect of displacement can be eliminated through the algorithm;the pressure on the collection site when the probe is fixed is monitored to ensure that the pressure on the collection site is consistent every time it is fixed,eliminating or weakening the pressure The impact on the results,and the real-time monitoring of the pressure during the detection process,can effectively avoid excessive changes in pressure due to the excessive amplitude of the object's activity,which will affect the detection resultsUsing a wearable probe for blood glucose experiments,during volunteer blood glucose rises,the system predicts blood glucose values and fingertip blood glucose values are increasing and the error is small,but during fingertip blood glucose declines,the system predicting blood glucose values are not decreasing significantly And there is a large error with the blood glucose value at the fingertips.During the entire prediction process,the maximum error between the predicted value and the fingertip blood glucose value was 0.698 mmol / l,and the minimum value was 0.02 mmol/l.2.In the course of the experiment,it was found that there was a large error when using the positioning label paper alone to select the area participating in the blood glucose calculation,so we introduced the NCC algorithm in combination with the positioning label paper to make up for the shortcomings.The NCC algorithm has a simple algorithm,high matching accuracy,and can obtain the precise position of the most matching area with the template,but it has a large amount of calculations.The use of positioning label paper has the advantages of fast positioning and simple operation.Therefore,the two are combined.The paper realizes coarse positioning,and the NCC algorithm realizes fine positioning,which provides positioning accuracy with an error of less than 5%.In the case of ensuring high-precision positioning,it will not consume too much time and meet the requirements of real-time blood glucose monitoring.