| Depression, a kind of syndrome that is characterized by persistent depressed mood, belongs to affective disorders. It is a common disease that harms the human physical and mental health. Its incidence rate has demonstrated a tendency of elevation with the development of society, the acceleration of the rhythm of work and life and the change of the life style. The investigation of modern medicine pathology makes it clear that the pathogenesis of the disease is complex and it is a kind of disease that multiple factor of biology, psychology and society leads to. Synthetic antidepressants have the flaws of single action, numerous ill effects and frequent relapse. Traditional Chinese Medicine (TCM ) described depression as a kind of gloomy syndrome thousands of years ago and has formed a complete theoretical system and accumulated a lot of therapy experiences on it. So it is need to summarize and discuss the causes, pathogenesis, therapeutic principles and therapeutic methods of depression from TCM, to do some clinic research and evaluate clinic effect with scientific method on some medical prescriptions that have doubtless good curative effect. All of these will be certain meaningful.Twenty depression suffers are divided into 2 groups in random in this study, 10 in Chinese drug group, 10 in western medicine drug group. The first are treated by Wangyou Jieyu Tang (WJT for short) for 2 weeks ,and the later by Dailixin. The diagnosis criteria is defined according to CCMD－Ⅲ criteria for depression and the diagnosis criteria about deficiency of both the heart and spleen of the depressed cycle of Bipolar depression established by Chinese Association of Integrated Traditional and Western Medicine. The accepted criteria are defined by referring to HAMD. Assess curative effect by HAMD. The symptom of TCM is evaluated by grade in pretreatment and post-treatment.The clinical research showed:(1)1 is healed, 3 have obvious effect, 3 are effective and 3 are useless in WJT group. The effective rate is 70％. 1 is healed, 5 have obvious effect, 2 are effective and 2 are useless in Dailixin group. The effective rate is 80％. There is no significant difference in two groups(P>0.05). (2)The results of HAMD show that total scores of post-treatment in WJT group and in Dailixin group are both remarkable lower compared to that of pretreatment(P<0.05).The first group average ratio of score reduced is 37％, and the later is 43%. There is no significant difference in two groups(P>0.05). (3)The results of factor analysis of HAMD show that WJT could ameliorate symptoms of sleep disorder ,anxiety / hypoergastic reaction and body symptomremarkably(P <0.05),but not apathy .Dailixin could ameliorate symptoms of sleep disorder ,anxiety / hypoergastic reaction, body symptom and apathy remarkably(P <0.05).(4)The analysis about comparison of sleep disorder in two groups shows that the amelioration of WJT is more remarkable(P <0.05).(5)The analysis about comparison of anxiety / hypoergastic reaction in two groups shows that the amelioration of Dailixin is more remarkable(P <0.05). (6) The analysis about comparison of body symptom in two groups shows that there is no significant difference(P <0.05). (7)The evaluation by grade about symptom of TCM in pretreatment and post-treatment shows that the amelioration of WJT is super to that of Dailixin in palpitation and sleeplessness(P <0.05). (8)1 had a dizziness in WJT group, but there is maybe nothing to do with the treatment .3 had side effect in Dailixin group.Conclusion:WJT and Dailixin can both ameliorate the symptom of depression significantly and there is no difference in two groups. The amelioration of sleep order is especially outstanding in WJT group. The result of this study shows that WJT treatme... |
PDF Full Text Request