Experimental Study Of Traditional Chinese Medicine Treatment Of Gouty Arthritis

Along with the increasing of Chinese people's living standard and the elongation of life span, the incidence rate of gouty arthritis shows rising tendency. Although gouty arthritis can be cured with Western medicine, patient can't take its consistently for apparent ill effect, so it's therapeutic efficacy is decreased. Many doctors have researched the gouty arthritis' treatment of the TCM, suggesting a lot of formulas to cure it. But these formulas aren't identical in the principle. For researching the effect of various formulas in treating gouty arthritis, we select mysterious tow powder, cinnamon twig decoction plus peony and anemarrhena decoction, poria five powder and san-tu decoction, which are various in the principle of the gouty arthritis' treatment, to observe the effect for the swelling of joint, pain and affected extremity pressure of gouty arthritis' model rat. The experiment process is as follow: 48 rats are divided into 6 groups randomly, as the mysterious tow powder group, the cinnamon twig decoction plus peony and anemarrhena decoction group, the poria five powder group, the san-tu decoction group, the dexamethasone group and the blank group, per group of animal number is 8. When MSU and Chinese medicine standard article had been prepared, injected MSU inside the left ankle joint cavity of all rats. 24 hours later, the rat model were made successfully, then observed all makers and registered its. Minutes later, the rats of the Chinese medicine groups began to be perfused corresponding prescription into its' stomach once daily for 3 days, the rats of the blank group were used saline; Dexamethasone was injected intraperitoneally both 1 hr before and 6 hr after the sodium urate injection to the ankle.96 hr after the model were made, observing all makers and registered its again. By comparing the difference tite of makers of each group, we find mysterious tow powder, poria five powder and san-tu decoction, whose main action are to disinhibit water and percolate dampness, have better effects., and among those formulas, san-tu decoction is better than others. But cinnamon twig decoction plus peony and anemarrhena decoction , which can dispel wind and eliminate dampness, clear heat and free the network vessels, is not good. So when treating gouty arthritis, we should conjugate identifying patterns and identifying diseases, not only refer to identifying patterns and administer treatment, establish the principle of the treatment, but also use some Chinese herb which is certificated to treat gouty arthritis, such as smooth greenbrier, shancigu bulbus. We also arrive at the result that gouty arthritis' main agent is damp turbidity and heat evil is another important agent. This result can help us to unify the cognition of gouty arthritis'etiological factor and pathomechanism.