Bitong Granules In Treating Rheumatoid Arthritis Clinical And Experimental Research,

Rheumatoid arthritis (RA) is one of the chronic general immunological disease, and the joint lesion in chief. It belongs to the category of Syndrome?in TCM. It may damage the tissues of the joints, such as cartilages, ligaments, muscle tendons and bones. Thus it can lower the living quality, even cause deformity. Because of the persistent course and chronic clinical duration, the heart, lungs, kidneys, arteries can be damaged and affect people's health seriously. At the moment, because of incomplete knowing the causes and mechanism of RA, we haven't effective cure now. But it shows fixed superiority in treating this disease by TCM. We carry forward the experience of the old famous TCM doctor Wang Luqiu, and advance stagnation of cold-damp and blood stasis obstructing in the channels is the pathologic change of RA. We prepared itongling?infusion by dispersing pathogenic cold and removing dampness, removing blood stasis and gredge the channels and collaterals by TCM theory .We inquire into its effect in clinical and experimental research. In Clinical Research, 80 RA patients involved ARA(1987) randomly divided in into treat group(Bitongling group,50 cases) and control group( Wang bi group,30 cases). The effective rate was 94%, which significantly surpassed the effective rate of the control group (73.33%), after 8 weeks treatment. itongling?infusion can remittence the symptoms of RA and ease their condition, such as arthralgia, morning stiffness, tenderness, arthrocele, weak grip strength and I 5m walking, it can lower ESR, the tiler of rheumatoid factor and immunoglobulin, and improve hemorrheological nature. With respect to these points, the treat group is better than the control group. In experimental research, we set up the model of adjuvant arthritis of rats, check up PGE2 content and SOD level concerned with the inflammation of RA. The statistic result shows bitongling?infusion can lower blood serum PGE2 content, raise SOD level, suppress arthrocele in feet of rats adjuvant arthritis. The experiment of anti-inflammatory, analgesia shows this infusion can relieve inflammation, and delay the pain threshold of mice. The pathologic result shows it can reduce invading of inflammatory cells, thus regulating immune. Clinical mid -Experimental Coneltzsion. "bitongling?infusion have functions-f anti-inflammatory, analgesia, regulating immune, and better effect on RA of acute stagnation of cold-damp.