Yue Treatment Of Menopausal Syndrome Mechanism Of Experimental Research. Menopause

AbstractObjectives:To study the therapeutic action on climacteric syndrome of Chinese herbal formula Geng-Nian-le (GNL), which can nourish the kidney, soothe the liver and invigorate Chong and Ken channels. Methods: According to the standard of nature climacterum model, we used l1-i5months old SD female rats as models. Meanwhile, we also selected 3 months old SD female rats as controls. Give GNL to some of the models, and give 0.9%NaCl solute to others. Hypothalamic monoaminic transmitters (NE, DA, 5-HT and 5-l-IIAA) contents were determined by high performance liquid chromatography and electrochemical detector. Serum E2, FSH, LU and IL-2 were detected by radioimmunoassay. Results:egulating the function of plant nerve: GNL can reduce hypothalamic 5-I-IT and 5-l-IIAA,which were increased in models (P < 0.0l-0.05) ;and it can increase reduced NE of hypothalamus in models (P < 0.05) ; also it can let the ratio of 5-HT to NE decrease nearly to the normal level group (P ?0.01) ;㏑egulating reproduction endocrine: GNL can evidently lighten ovary atrophy degree, improve serum E2 level and obviously lower serum FSI-I and LU levers of model rats.?Improving immunity: GNL can increase the content of serum lL-2 in models (P < 0.05) and lighten the atrophy degree of their thymus. Conclusions: By means of regulating thd function of plant nerve and reproduction endocrine and improving immunity, GNL may produce an effect on nerve-endocrine-immune network by various levels, ways and links. So it can stabilize inner condition of body and relieve symptoms of climacteric syndrome.