| Object: By contrasting the influence of 1CM of promoting blood circulation to remove blood stasis and colchicines on the level of tumor necrotic factor (TNF- a) and interleukin(IL- I ) in knee-joint fluid of rabbit with acute gouty arthritis, discussing the mechanism of TCM of promoting blood circulation to remove blood stasis and on treating acute gouty arthritis proving obstruct due to obstruction of collaterals by blood stasis as the main mechanism of acute gouty arthritis. Method: 32 rabbits were divided into 4 groups randomly by injecting urate potassium MUS knee-joint cavity pathological model of acute gouty arthritis was formed contrasting treatment with 1CM of promoting blood circulation to remove blood stasis and colchicines was made sampling was taken divided at 2h. 6h. 9h. 12h, ELISA was used to detect the level of TNFæ¢ and IL-i in knee-joint fluid of every time. Result: 1. the level of TNF-a and IL-i P of model group was significantly higher than that of 1CM group and colchicines group, the difference was significant (p |