Based On Data Mining To Explore The Prescriptions And Medication Rules Of The Method Of Promoting Blood Circulation And Removing Blood Stasis In The Treatment Of Dyslipidemia

Purpose:Based on data mining technology,explore the medication and prescription rules of blood lipid abnormalities treated by the method of activating blood circulation and removing blood stasis,and explore the effects of potential new prescriptions to provide reference for clinical treatment of abnormal blood lipids.Material and method:In accordance with the methods and procedures of document retrieval,this study retrieved "CNKI","Wanfang Data Knowledge Service Platform","Vip Information Chinese Journal Service Platform","Superstar" from October 1,2000 to October1,2020.All the documents that can be retrieved in the "Journal" document library,select the documents that meet the inclusion and exclusion criteria,sort the selected documents,extract the article name,author,publication year,prescription name,drug composition and other information,and create an Excel table,Use the data mining technology of the TCM Inheritance Assistant Platform(v2.5)to analyze the included data,analyze and discuss the results and draw conclusions,and explore the drug rule of treating dyslipidemia from the blood stasis theory.Results:A total of 113 prescriptions were included in this study,including a total of 117 traditional Chinese medicines.The results are as follows:1.The top 10 prescription Chinese medicines are: Danshen(78 times),Hawthorn(65 times),and safflower(48 times),Chuanxiong(48 times),Red Peony(44 times),Astragalus(39 times),Angelica(39 times),Alisma orientalis(38 times),Pinellia(36 times),Peach kernel(36times).2.The order of the four Qi frequencies of the drugs in the prescription is: warm(507 times),cold(328 times),calm(226 times),cold(57 times),and hot(1 time).3.The ranking of the five flavors of traditional Chinese medicine prescriptions are: sweet(599 times),bitter(583 times),pungent(408 times),acid(122 times),salty(62 times),and astringent(28 times).4.The first four returning to menstruation are: liver(701 times),spleen(503 times),heart(388 times),and stomach(356 times).5.Through the analysis of Chinese prescriptions in the traditional Chinese medicine inheritance auxiliary platform system-the rules of formulating,the top ten combinations of Chinese medicine compatibility in the entered prescriptions are:(1)Salvia and Hawthorn(54 times);(2)Alisma and Hawthorn(35 times);(3)Salvia miltiorrhiza,Alisma orientalis(32 times);(4)Red peony root,Ligusticum chuanxiong(31 times);(5)Salvia miltiorrhiza,Alisma orientalis,Hawthorn(31 times);(6)Salvia miltiorrhiza,Astragalus(30 times);(7)Chuanxiong,Angelica sinensis(29 times);(8)Banxia,??Salvia miltiorrhiza(29 times)(9)Red peony root,Angelica sinensis(29 times)(10)Safflower,Chuanxiong(28 times).6.Obtained 10 new drug pairs and 5 potential new prescriptions:(1)Astragalus,Angelica,Cassia,Earthworm,(2)Notoginseng,Guizhi,Rhodiola,Dalbergia odoratum,(3)Atractylodes,Alisma,Polygonum,Licorice,(4)Bupleurum,Cymbidium,Turmeric,Leech,Rhubarb,Polygonum cuspidatum,(5)Peach kernel,hawthorn,red peony root,Chuanxiong,Eupatorium Conclusion:1.Through data mining,the drugs used for the treatment of dyslipidemia with the method of activating blood circulation and removing blood stasis are obtained.The four qi are mainly warm,and the five flavors are mainly sweet.Most of the meridians belong to the liver and spleen meridians.2.Most high-frequency drugs are mainly based on promoting blood circulation and removing blood stasis,and supplemented by products for replenishing qi,lightly infiltrating and removing dampness,reflecting the characteristics of taking into account the specimen.In addition,modern pharmacological studies of high-frequency drugs have a lipid-lowering effect.3.Potential new prescriptions provide a brand-new treatment plan for future clinical drug selection,which is worthy of reference.