| Objcctive To observe 1lost tIbl.ovascularizatio11 ()fllydl.oxyapatite orbital impla11ts wl'aped in PLGA[75/25 P()ly (I,L-. feasibi1ity. Methods Tlle l-abbits had one eye enucleated all(l tl1e1lreceived a l0-m1n hydroxyapatite in1plallt wl'apped iIl PLGAllleIl1bl-a11e. Four a11i1nals wel-e kil1ed at 2, 4, 8 5 12 J a11d 24 wccksafte1- il11Plal1tatio11,al1d tl1e il11I)lallt was 1ielnoved fOr l1istoI3atll()l()gica1exn111il1ati()l1. Results 'ltlle coljul1ctival wound al1d l11uscu1:[l' tiRsuc' were ndl1ere11t firlnly to tlle PLGA l11el1lbrane ol, tlle llydroxy:1l)atitc()bitnl illlI)Inllt. TIle degree of fibrovascularizatiofl was substal1ti[1l illall tlle sPecilllel1s, a11d lol1ger was tlle period, tl1e degl-ce ()t'l'ibl.()vnscularizatiol1 flPl)eal-ed greatel'. A gl.allulol11:lt()[ls li)l'cig11-l)ot1y giallt--cell reactioll to both tl1e PLGA mel11[)ra11e a11cl t11cilllI'[a11(itsclf was prese1lt up to'8 weeks after i111l)laIltati()ll. J'l-,GAlllel1ll)I-a11e stal.ted to be absorbed at 8 weeks after il11I)lfl11I;lti()11.There were no postoperative infection, no exposure and exclusure ofimplants. Conclution Host fibrovascularization of PLGA-membrane-wraped hydroxyapatite implants in the rabbit appears tobe the same as it of donor sclera-wraped ones. PLGA membrane isan accetable alternative wrap for the hydroxyapatite implant,eliminating the need fOr dollor sc1era and the potential risks oftransmissible diseases involved in using donor tissue. |
