Comparative Study Of Injection Via Different Vessels To Show Accular Aneurysm In Rabbits

Background：Intracranial aneurysm is a very common disease. Autopsy studies have shown that theoverall frequency in the general population ranges from1to5percent. Most of the patientsare ranging from40to60, and the ratio between men and women is2:3. Just followedCerebral thrombosis and Hypertensive intracerebral hemorrhage, intracranial aneurysm rankthird in patients who suffer from cerebrovascular accident.It has high morbidity andmortality which imposes great loads on families ana society. The symptoms include thereaspects which are hemorrhage, ischemia and mass effects. CTA (computed tomographyangiography) and MRA (magnetic resonance angiography) were more and more used todiagnosis this disease, but DSA (Digital subtraction angiography) is still the golden standard.There are there choices to treat intracranial aneurysms including conservative treatment,clipping and embolizing. In2002ISAT (International Subarachnoid Aneurysm Trial)reported that there is no differences in mortality and recurrence at one later after surgerybetween surgical treatment and endovascular treatment. However endovascular dramaticallyimprove the quality of life of the patients with little invasiveness. Recently embolicaltechniques and materials have made great progress,including remodling, stent, coated coils,liquid embolical materials and so on.It is especially important to evaluate medical functionand safety of embolid techniques and materials.It is also important to make animal aneurysmmodel which are similar to human aneurysms in histology and haemodynamic.Elastae-inducee aneurysm model in rabbits are very similar to human aneurysms inmorphology, pathology, haemodynamic, clinical manifestations. They are very cheap andeasily acquired, which are broadly used in every aspects of aneurismal research. How tocorrectly evaluate therapeutic effect of embolical aneurysms is critical to assess medicaleffect of embolic materials. Image and pathology are means to evaluate therapeutic effect ofembolical aneurysms. Image is mainly mean in long term follow-up of embolical aneurysms,which incude DSA, CTA, MRA. DSA divide into femoral arterial angiography, ear marginvein angiography in rabbits, middle arterial angiography in rabbits ear, and femoral arterialangiography is gold standard.However bilateral femoral arteries have been ligated afterembolization, and there is statistical difference among femoral arterial angiography, ear margin vein angiography in rabbits, middle arterial angiography in rabbits ear. Ear marginvein angiography in rabbits and middle arterial angiography in rabbits ear cannot comparewith femoral arterial angiography in image resolution. Vertebrobasilar artery system mainlysupply brain in rabbits, accounting for approximate80%, while bilateral common carotidarteries account for20%in blood supply. Left carotid artery adjacent to model aneurysms inrabbits, so we will show elastase-induced aneurysms in rabbits through left common carotidartery, and analyse its feasibility and treatmen effect.Purpose：Investigate the feasibility of showing saccular aneurysms in rabbits through leftcommon carotid artery, and compare features of different angiography ways to showsaccular aneurysms in rabbits.Methods：We made model aneurysms in ten china rabbits through ballon occlusion technique andelastase.We show model aneurysms separately through left femoral artery angiography, right earmargin vein angiography, left middle artery in rabbits ear, and left common carotid artery.Two radiological doctors separately measure the width, length and neck width withmeasuring apparatus in DSA workstation, and take average as results.Results：There is no statistical difference between contrast via femoral artery anc left commoncarotid artery in showing width, length, neck width of model aneurysms. However, therehave a statistical difference between contrast via femoral artery and left ear middle artery,righe ear margin vein.Conclusions：Contrast via left common carotid artery could replace contrast via lefe ear middle arteryor right ear margin vein, and become the main way of evaluating model aneurysms infollow-up.