Acupuncture Treatment Of Colorectal Cancer Patients With Oxaliplatin-based Chemotherapy Induced Peripheral Neuropathy In Clinical Studies

Peripheral neuropathy is one of the common side effects of chemotherapy drugs. In severe cases it can even affect the daily lives and the quality of life of cancer patients who have received chemotherapy. Peripheral neuropathy could cause some common clinical symptoms such as decreased sensation,numbness of extremities, paresthesia, pain, etc.MG, muscle cramps, myalgia, and even paralysis can be seen in some patients.The incidence of peripheral neuropathy is often associated with the cumulative dose and intensity, the neural toxicity limits the dosage of chemotherapy, which seriously impedes the completion of chemotherapy and reducing the efficiency of chemotherapy.peripheral neuropathy caused by oxaliplatin and paclitaxel is the most common kind in clinic.So far, there is no effective treatment for peripheral neuropathy. The most important thing is to find effective drugs and methods for the treatment of peripheral neuropathy.Recently many studies indicates that several drugs for treating. Chemotherapy induced peripheral neuropathy have been found. But most of these studies have faults,such as the number of cases is small, there are no controls, large random controlled Experiments are needed to confirm the effect of those drugs. In fact, there is no clinical effective drugs to prevent peripheral neuropathy, so far, Chinese medicine have been widely used in the treatment of all sorts of peripheral neuropathy, and they have already demonstrated much advantage in treating peripheral neuropathy caused by diabetes. Although peripheral neuropathies are caused by different reasons, their pathogenesis and clinical manifestations are similar.peripheral neuropathy are subscribed to "Numb","Bi disease", "atrophy "category in Chinese medicine, the therapies include circulating meridians, nourishing qi and circulating blood, nourishing blood and softing tendons. Currently, there are not many researches on acupuncture treatment of peripheral neuropathy,so researches on acupuncture treatment for chemotherapy drug-induced peripheral neuropathy are much les. there are advantages of low cost and easy operation with Acupuncture, and cancer patients after chemotherapy often have gastrointestinal reactions and difficulties in medication, most patients are willing to accept acupuncture treatment.Objective:To observe clinical effects of acupuncture treatment on colorectal cancer patients with peripheral neuropathy (CIPN) induced by L-OHP in chemotherapy and explore the differences among varied degrees of CIPN.Method:60 participants meet the criteria based on randomized controlled trail. They were randomly and evenly divided into two groups:acupuncture group and western medicine group. In acupuncture group, points of hand and foot yangming channels were mainly selected, while cobamamide was injected into muscle in western medicine group. Referring to grading standard of CIPN Patient Questionnaire, the grading scores before and after treatment were recorded and made a comparison. Results were analyzed by SPSS software.Results:1. The total effective rate of acupuncture group on sensory nervous dysfunction was 70.00%, while that of control group was 46.67%. However, there was no statistics significance of total effective rate and therapeutic effect between two groups (P=0.066, P>0.05).2. The total effective rate of acupuncture group on motor nervous dysfunction was 13.33%, whereas in control group, it was 6.67%. Result indicated that there was no statisti difference between two groups (P=0.393, P>0.05).3. In acupuncture group, among all participants with peripheral neuropathy, which of grade was 14 cases (effect:10); grade 2 was 12 cases (effect 6, significant effect 2); grade 3 was (effect 1, significant effect 2) (P=0.115, P>0.05). Statistics of effective rate showed there w no significant difference among varied degrees of CIPN.Conclusion:The total effective rate of acupuncture treatment of L-OHP induced neuropathy is higher tha that of the control group. There is no statistics difference between two groups. Acupunctu treatment has the same therapeutic effect on the cases with different degrees of CIPN(?) L-OHP.