| Objective:â‘ observing the therapeutic effects of acupuncture on the treatment of chemotherapy-induced peripheral neuropathy.â‘¡investigating evaluation methods of CIPN.Method: 64 cases of paclitaxel or oxaliplatin induced peripheral neuropathy were divided into treatment group (32 cases) and control group (32 cases). The principle of acupuncture group is dredging meridians, promoting blood circulation, removing blood stasis, supplementing kidney and liver,tonifying blood and moisting tendons. The control group was treated with intramuscular injection of Cobamamide. Referring to the World Health Organization Toxicity Criteria by Grade and CIPN Patient Questionnaire, the grading scores before and after treatment were recorded and made a comparison after two weeks. The result was analyzed by SARS software.Results:1. According to the World Health Organization Toxicity Criteria by Grade, the result shows that there is no difference between two groups P=0.328(P>0.05). The total effective rate of treatment group is 40%, and control group is 26.67%.2.â‘ According to the CIPN Patient Questionnaire, the result of sensory neuropathy shows that there is a difference between two groups P = 0.047(P<0.05). The total effective rate of treatment group is 66.67%, and control group is 40%.â‘¡The total effective rate of paclitaxel induced sensory neuropathy on the treatment of acupuncture is 88%, and and that of oxaliplatin is 39%. The effective patients who were induced by paxlitaxel with the treatment of acupuncture include 3 cases of grade 4, 4 cases of grade 3, 8 cases of grade 2, 0 case of grade 1.â‘¢The sensory neuropathy caused by paclitaxel is much severe than that caused by oxaliplatin. Part of the paclitaxel induced sensory neuropathy affects daily activities.â‘£The motor neuropathy improvement of both two groups is not obvious. The total effective rate of treatment group is 26.67%, and control group is 11.76%.Conclusion: The CIPN Patient Questionnaire is more accurate than World Health Organization Toxicity Criteria by Grade on the aspect of evaluating neurotoxicity. Acupuncture is more effective than Cobamamide on the treatment chemotherapy induced sensory neuropathy. The total effective rate of acupuncture on the treatment of paclitaxel induced sensory neuropathy is higher than that of oxaliplatin. Acupuncture is effective on the treatment of moderate and severe paclitaxel induced sensory neuropathy. Acupuncture can improve the symptom of chemotherapy induced sensory neuropathy. Further studies about paclitaxel induced peripheral neuropathy are expected. In future, there are more expections on larger population study in order to confirm the effect of acupuncture on the treatment of CIPN. |
