Polymorphism Of Caspase-3 -928a/g Associated With The Risk And Aggressiveness Of Colorectal Cancer In Chinese Population

Objective: Caspase-3, a primary effecter CASP that executes programmed cell death, plays an important role in the development and progression of the cancer. This study was to investigate whether the Caspase-3 -928A/G polymorphism was associated with colorectal cancer in Hubei population.Methods: This study was based on a case-control study. We carried out polymerase chain reaction-restriction fragment length polymorphism in blood genomic DNA of 161CRC patients and 159 control subjects. The relationship of different genotypes with the susceptibility of colorectal cancer was analyzed.Results: The genotype frequencies for -928 AA ,AG and GG were 49.70%,45.30%,5.00%in CRC, and 30.80%,56.00%,13.20% in healthy subjects. Respectively, the frequencies of Caspase-3 -928Aallele genotype was significantly higher in CRC than in healthy subjects. [72.36%vs58.81% , P=0.013,OR=0.338,95%CI:0.144-0.792]Conclusions: These results suggested that genetic variation in Caspase-3 -928 may contribute to CRC. The Caspase-3 -928AA could be used as a genetic risk marker for the metastasis of CRC patients.