Research And Application Of Synthetical Evaluation In The Down's Syndrome Screening System

Bioinformatics is the interdiscipline of computational molecular biology and information processing science. With the rapid development of computing techniques, biological technologies are reshaping the human society. It brings new development for the screening of Down's syndrome by combining the computing techniques with the bioinformatics.Down's syndrome is an usual chromosome disease, because of the abnormality of fetus' chromosome. It will take big tragedy to the family. So it is a very meaningful job to study the method of screening the DS in the first and second trimester, especially using the computing technique.The workload of the collection, statistics and analyzing for the information can be depressed through using the DS screening software. The accuracy of the screening result is also improved. Using the software, the data can be stored integrally. This is useful for the further study and diagnoses.The information for screening DS in the pregnancy period and the revise information are concluded here, the main point and innovation are listed below:1. The measures, used for screening DS pregnancies in the first and second trimester has been concluded here;2. The information related to the DS in the first and second trimester has been concluded here , such as ultrasonic screening methods , maternal serum biochemistry;3. The efficacy of the respective information are analyzed by combining theory of information and synthetical evaluation;4. The screen information and its revise information for our system has been chosen though the statistical methods, using single diathesis methods and multiple diathesis methods;5. Three screen fields were evaluated by meta-analysis method. After the evaluation, the best field has been chosen for the further study;6. The function of the screening system is realized at last though the software. This screening system is used for determining the risk of DS pregnancies in thesecond trimester, the risk of the NTD pregnancies is determined at the same time. It is proved that this system is according to the requirement of the DS screening system.