| Purpose: Investigate the distribution law and general clinical features of different TCM syndromes in the patients with diabetic lower extremity arteriosclerosis occlution(DLASO),and analysis of the relationship between different TCM syndromes and relevant factors of age,sex, blood lipids,hemoglobin A1 c,in order to provide an objective basis of targeted research for the future and provide guidance and assistance for the clinical Integrative Medicine.Material and method:According to the diagnostic criteria,the inclusion criteria and exclusion criteria of this study,collect the hospitalized patients with DLASO in Department of Endocrinology in Jinzhou Central Hospital from September 2014 to September 2015. There are 86 patients in diagnosis of DLASO by color Doppler ultrasound and CTA.According to 《Guidelines of diabetic clinical research of Traditional Chinese Medicine》 and 《Diagnostics of Traditional Chinese Medicine》,with clinical diagnostic and treatment practices developed by Affiliated Hospital of Liaoning University of Traditional Chinese Medicine Endocrinology,DLASO were divided into three groups: deficiency of both Qi and Yin with blood stasis group,humid and heat trapped spleen with blood stasis group and deficiency of both Yin and Yang with blood stasis group.Analyze and summery the group of 86 patients with four diagnostic methods,deficiency of both Qi and Yin with blood stasis group 35 cases, including 22 males and 13 females;humid and heat trapped spleen with blood stasis group 27 cases, including 19 males and 8 females;deficiency of both Yin and Yang with blood stasis group 24 cases, including 15 males and 9 females.By general summary of the 86 patients clinical datas(such as age,course of DM,BMI,edg),and laboratory indicators include fasting plasma glucose, total cholesterol, triglycerides, HDL-C, LDL-C, hemoglobin A1 c,and build the database.Results: 1.General situations:The constituent ratio of three TCM syndromes are sorted from high to low as deficiency of both Qi and Yin with blood stasis group﹥humid and heat trapped spleen with blood stasis group﹥deficiency of both Yin and Yang with blood stasis group,the difference is statistically significant(P<0.05).The study includes patients 86 cases, male to female ratio is 1.87: 1, and the difference is statistically significant(P<0.05).The patients were divided into the middle segment(45-59 years old), the elderly segment(60-79 years old) and the very elderly segment(≥80 years old) in three stages by age.There were 15 cases in the middle segment(accounting for 17.44% overall),59 cases in the elderly segment(accounting for 68.60% overall),12 cases in the very elderly segment(accounting for 13.96% overall),and the elderly segment has statistical significance compared with other groups(P<0.05). 2.The situations of complications:The study included 80 patients with Diabetic Peripheral Neuropathy, in the first place by complications, accounting for 93.02% overall;followed by 58 cases of Hypertension, the prevalence ratio reached 67.44%;Others Hyperlipidemia were 52 cases(60.47%), Diabetic nephropathy in 41 cases(47.67%), Cerebrovascular disease in 25 cases(29.07%), 19 cases of Coronary Heart Disease(22.09%).The chi-square test calculated that, Hyperlipidemia, Diabetic nephropathy and Coronary Heart Disease in the differences between groups were statistically significant(P<0.05).By pairwise comparison,the differences of deficiency of both Yin and Yang with blood stasis group between deficiency of both Qi and Yin with blood stasis group and humid and heat trapped spleen with blood stasis group have statistically significance(P<0.05) in Hyperlipidemia;the differences of deficiency of both Qi and Yin with blood stasis group between humid and heat trapped spleen with blood stasis group and deficiency of both Yin and Yang with blood stasis group have statistically significance(P<0.05) in Diabetic nephropathy and Coronary Heart Disease.There was no statistical significance in the risk of Diabetic Peripheral Neuropathy, Hypertension and Cerebrovascular disease.3.The comparison of clinical datas:In the terms of age and TG, the differences of deficiency of both Qi and Yin with blood stasis group between humid and heat trapped spleen with blood stasis group and deficiency of both Yin and Yang with blood stasis group have statistically significance(P<0.05).In the terms of BMI, the difference between deficiency of both Qi and Yin with blood stasis group and deficiency of both Yin and Yang with blood stasis group was statistically significant(P<0.05).Both in FPG and Hb A1 c,the differences of deficiency of both Yin and Yang with blood stasis group between deficiency of both Qi and Yin with blood stasis group and humid and heat trapped spleen with blood stasis group have statistically significance(P<0.05).In terms of TC and LDL-C, the differences of deficiency of both Yin and Yang with blood stasis group between deficiency of both Qi and Yin with blood stasis group and humid and heat trapped spleen with blood stasis group have statistically significance(P<0.05).Both in HDL-C and the course of DM,pairwise comparisons among the three groups, the differences were not statistically significant.Conclusion: 1.The most common syndrome in DLASO is the deficiency of both Qi and Yin with blood stasis.The risk of suffering from DLASO for male is higher than female in DM.The main hospitalized population is the elderly segment(60-79 years old). 2.Patients of the humid and heat trapped spleen with blood stasis group and the deficiency of both Qi and Yin with blood stasis group are easier combined with Diabetic nephropathy and Coronary Heart Disease than patients of the deficiency of both Qi and Yin with blood stasis group. 3.Patients of the humid and heat trapped spleen with blood stasis groups and the deficiency of both Yin and Yang with blood stasis group are older than patients of the deficiency of both Qi and Yin with blood stasis group. |
