Clinical Characteristics Of Diabetic Lower Extremity Arteriosclerosis Occlusive Disease

Objective:Discuss the clinical features of diabetic lower extremity arteriosclerosis occlusive disease.Methods:Collecting the clinical information of 132 patients with lower extremity arteriosclerosis occlusive disease (LEASOD), such as the history of hypertension,diabetes mellitus (DM),ABI value, gender, age, coronary heart disease,stroke and locus of pathological change and so on.All subjects were divided into two groups:the group of diabetic patients (DM) and the other group of patients without diabetes(NDM).Compared according to different indicators:①.age;②.sex ratio;③.The clinical testing index:blood pressure (SBP/DBP), plasma lipids (TG/TC), fasting plasma glucose, HbA1c, fasting plasma insulin;④.lesions degree:All subjects were divided into three groups based on ABI values,0.7≤ABI≤0.9 for mild LEASOD group,0.4≤ABI<0.7 as moderate,ABI<0.4 for severe;⑤.lesions type:Type-Ⅰ, lower extremity atherosclerosis involving superficial femoral artery and the arteries proximal to it; Type-Ⅱ, simply involving the superficial femoral artery; Type-Ⅲ, involving the superficial femoral artery and the arteries distal to it; Type-Ⅳ, involving multifocal atherosclerotic changes of the lower extremity;⑥.complications:smoking;hypertension;coronary heart disease;stroke and so on.Results:1.The mean age of atherosclerosis onset was earlier in the group of diabetics than the group of patients without diabetes(P=0.007).2.The ratio of male to female was 4.7:1 in group of diabetics and 6.5:1 in group of patients without diabetes(P=0.731).3. Blood pressure, fasting plasma insulin with no significant difference between the group of diabetics and the group of patients without diabetes(P>0.05).Plasma lipids (TG/TC), fasting plasma glucose, HbAlc were higher in the group of diabetics than the group of patients without diabetes(P<0.05).4.Between the two groups lesions degree difference statistically significant (P=0.015). Mild to see more in group of patients without diabetes(53.1%),the group of diabetics severe see more(50.0%).5.The arteries below knee were involved in most diabetics and the arteries above knee were involved in most patients of the other group(P<0.001). Type-Ⅰlesion, lower extremity atherosclerosis involving superficial femoral artery and the arteries proximal to it, was more commonly seen in the patients without diabetes(P=0.002); Type-Ⅱlesion, simply involving the superficial femoral artery, was also more common in the patients without diabetes(P=0.014); Type-Ⅲlesion, involving the superficial femoral artery and the arteries distal to it, was more common in the diabetics(P<0.001); Type-Ⅳlesion, involving multifocal atherosclerotic changes of the lower extremity, was more common in the diabetics(P=0.021).6.Percentages of the diabetics and patients without diabetes had the concomitant diseases respectively as follows:55.9% and 65.3% with smoking (P>0.05),52.9% and 60.2% had hypertension (P<0.05); 20.6% and 6.1% had coronary heart disease(P<0.05); 14.7% and 19.4% had stroke(P>0.05).Conclusion:Diabetes patients than the patients without diabetes of arteriosclerosis onset ages in advance, has higher levers of glucose and lipid,also the heavier Cardiovascular complications and lesions conditions.Diabetes tends to affect the arteries distal to the superficial femoral artery with multifocal involvement...