Study On The Clinical Study Of CKD3-4 Treated By

Purpose:To explore the centralizer to evil treatments for chronic kidney disease(CKD) 3-phase 4 clinical effect, providing theoretical basis for clinical treatment of traditional Chinese medicine in the future work.Material and method:Selected in January 2014- May 2015, our hospital 3- 4, 150 cases of patients with chronic kidney disease(CKD). Selected patients using the random number table method was divided into control group and observation group, 75 cases in each group. 55 cases of control group in patients with men, women, 20 patients with age 36-70, the average age was(49.52 + 5.24), the course of 2 to 6 years, the average course was(3.29 + 1.75) years; Male 58 cases in observation group of patients, 17 were women, aged 37-69, the average age was(50.61 + 5.19), the course of 3 to 6 years, the average course was(3.34 + 1.78) years. Two groups of patients with general data comparison difference has no statistical significance(P > 0.05). Selected cases met diagnostic criteria. Two groups of patients with reference to clinical guidelines, all give diet control, diuresis, anti-infection and correction of metabolic acidosis, suit the support intervention; Two groups of patients are hydroxy benzene sulfonic acid calcium capsules,0.5 g day three meals in oral.On the basis of the control group patients to hai kun renal capsule oral,three times two day. Observation group of patients, to add to the centralizer medicinal broth of traditional Chinese medicines to evil method as the main treatment of treatment, drug composition for: 15 g twotooth achyranthes root, radix astragali 30 g, patchouli, 10 g, 10 g perrin, amomum villosum 6 g, 15 g, poria cocos pinellia 10 g, 15 g yam, dogwood, 10 g, 12 g, cortex moutan, salvia miltiorrhiza, 10 g, rhubarb, 9 g, cogongrass rhizome 30 g, pseudostellaria root, 20 g leonurus 15 g, dodder 10 g, 15 g atractylodes, 15 g dried tangerine or orange peel, pangolin scales, 5 g, dandelion, 10 g, calcined oyster 20 g, water 1000 ml decoction to 300 ml of 1 agent, morning and evening meal served; Two groups of patients in 4 weeks for a period of treatment, a total of four courses of treatment. After the treatment were observed and compared the two groups of patients with clinical symptoms integral, related parameters of renal function, including the endogenous creatinine, endogenous creatinine clearance, and the improvement of blood urea nitrogen, and calculate the total effective rate, comparing the difference between the two groups of clinical curative effect. Using SPSS16.0 statistical software for statistical analysis of measurement data to((?)±s) said, measurement data comparing two take test; Count data to rate, said to take chi square test, as a result, P < 0.05 difference is statistically significant.Results:1.Compared two groups of patients with clinical efficacyIn the two groups after treatment in patients with symptoms and signs were improved, but the experimental group improved more obviously. The control group in patients with 15 cases were markedly effective, effective 27 cases, 33 cases, treatment the total effective rate was 56.00%; Observation group of patients in 22 cases were markedly effective, effective 35 cases, 18 cases, the total effective rate was 76.00%; Observation group of patients with clinical efficacy significantly better than control group, P < 0.05,the difference was statistically significant.2.Two groups of patients before and after treatment, symptom integral comparisonComparing the two groups after treatment of traditional Chinese medicine symptom integral, comparison of traditional Chinese medicine symptom integral were lower in the group,P < 0.05,the difference was statistically significant; But outside the group comparison of TCM symptom integral of observation group was obviously lower than the control group, P < 0.05,compared the result difference between groups was statistically significant, indicating that group in the traditional Chinese medicine symptom integral was observed obviously better than the control group.3.he two groups before and after treatment in patients with renal function index levelComparing the two groups after treating kidney related index level, within the group to compare the endogenous creatinine, blood urea nitrogen indexes were reduced, endogenous creatinine clearance index was increased, P < 0.05,the difference was statistically significant; But the comparative observation group of endogenous creatinine, blood urea nitrogen indexes significantly lower than the control group, the endogenous creatinine clearance index is significantly higher than the control group, P < 0.05,compared the result difference between groups with significant difference, indicating that the experimental group in the related parameters of renal function level improved significantly superior to the control group.Conclusion:The centralizer herbal medicinal broth to evil law have the benefit spleen and kidney, activating blood, water, drainage turbidity of detoxification effect, can effectively relieve the clinical symptoms and signs, improve renal function, reduce serum creatinine(Scr), blood urea nitrogen(BUN), obviously increase the endogenous creatinine clearance, to give a guidance of clinical, have clinical application value.