| ObjectiveDyslipidemia is an important risk factor for atherosclerosis, the formation of atherosclerosis eventually led to the occurrence of cardiovascular and cerebrovascular diseases.About homocysteine(Hcy) mumerous studies also have shown that the rise of Hey levels is another cause of atherosclerosis risk factors.At present research findings on the correlation between Hey levels and lipid levels are inconsistent,And more to the research of "the disease",namely the study of the correlation of coronary heart disease, hypertension, cerebral infarction and Hey level are more, for the "not ill" state of research is relatively small, namely for the simple dyslipidemia and Hey correlation is less. This paper respectively from the perspective of both Chinese and western medicine to explore the correlation of simple dyslipidemia and Hey levels.Clear simple dyslipidemia in patients with serum Hey levels and the correlation between TCM syndrome type.From "prevention of disease" point of view, evaluation of lipid indexs combined serum homocysteine detection on the guidance of clinical value, so as to provide more evidence for the prevention, detection of atherosclerotic disease and for the treatment of dyslipidemia TCM offers new ideas and evidence.MethodIncluded in the April 2015 to January 2016 visit to Beijing University of Chinese Medicine Dongzhimen Hospital simple dyslipidemia 122 patients and healthy 40 cases, respectively, as the case group and the control group. Acquisition of the patient’s general information, In the second day after admission fasting venous blood specimens of two groups serum lipids TC,TG,LDL-C,HDL-C and serum Hey were determined.Referring to"Chinese new drug clinical research guidelines (Trial)" (2002) collected information on cases related symptoms in patients, fill Syndrome Rating Scale score and differentiation. Finally, the collected data were analyzed by using SAS9.30.Result1.In the 122 cases of simple dyslipidemia patients, age distribution in middle-aged and old. In patients with dyslipidemia youth group the number of menmorethan thewomen, middle-aged and old group the number of women more than men.2. Dyslipidemia Syndrome Patterns Distribution:122 cases were included in the group, sputum Stasis Syndrome in 42 cases,accounting for 34.4%; Spleen deficiency syndrome in 31 cases, accounting for 25.4%; Qi stagnation and blood stasis syndrome in 16 cases, accounting for 13.1%; No syndrome 14 cases, accounting for 11.5%; Liver and kidney yin deficiency syndrome in 13 cases, accounting for 10.7%; Yin deficiency and yang hyperactivity syndrome in 6 cases, accounting for 4.9%.3.Relationship of the syndrome and lipid indexs of patients of dyslipidemia:Among syndromes TC compared:Qi stagnation and blood stasis syndrome group had the highest level of TC, No syndrome group TC had the lowest levels, the difference was statistically significant (P<0.05),qi stagnation and blood stasis syndrome group was no significant difference between groups with other syndromes(P>0.05). Among syndromes TG compared: sputum Stasis Syndrome group had the highest level of TG,statistically significant differences between groups with other syndromes (P<0.05). Among syndromes HDL-C compared:putum Stasis Syndrome group had the highest level of HDL-C, Liver and kidney yin deficiency syndrome group HDL-C had the lowest levels, the difference was statistically significant (P＜0.05), putum Stasis Syndrome group and other groups was not statistically syndromes significance(P>0.05); Among syndromes LDL-C compared:Qi stagnation and blood stasis syndrome group had the highest level of LDL-C, No syndrome group LDL-C had the lowest levels,Qi stagnation and blood stasis syndrome group with Yin deficiency and yang hyperactivity syndrome group has no statistically significant(P>0.05), Qi stagnation and blood stasis syndrome groupand spleen deficiency syndrome group, Liver and kidney yin deficiency syndrome group, putum Stasis Syndrome group, No syndrome group difference was statistically significant (P<0.05).4.Comparison between case group and control group of Hey levels:The average of the case group Hcy was 11.85±4.36μmol/L, up to 32.8μmol/L, the lowest 7.0μmol/L. The average of the control group Hcy was9.60±1.69μmol/L, up to 12.4μ.mol/L, the lowest 6.1 μmol/L,Hcy levels are within the normal range.The difference of Hcy between the the case group and the control group was statistically significant (P<0.05).5. Comparison among different syndrome types of Hcy levels:putum Stasis Syndrome group and qi stagnation and blood stasis syndrome group Hcy level was no significant difference(P>0.05); spleen deficiency syndrome group, Liver and kidney yin deficiency syndrome group, yin deficiency and yang hyperactivity syndrome group, no syndrome group Hey level was no significant difference(P>0.05); putum Stasis Syndrome group,qi stagnation and blood stasis syndrome group and spleen deficiency syndrome group, liver and kidney yin deficiency syndrome group,yin deficiency and yang hyperactivity syndrome group, no syndrome group Hey level difference was statistically significant (P<0.05).6. Distribution of Hey levels in case group:122 patients in the case of high Hey levels are 16 cases, Hey levels are within the normal range of 106 cases. According to different levels of Hey state groups, which is less than10μmol/L in 49 cases (40.2%),10-15μmol/L for 57 cases (46.7%),greater than 15μmol/L for 16 cases (13.1%). The higher Hey levels within the normal range at most, and the high levels in the putum Stasis Syndrome group and qi stagnation and blood stasis syndrome group.7. Case group Hey levels of different gender:male patient group Hey level was 13.43±5.37μmol/L, female Hey level was 10.71±3.01μmol/L, male Hey levels higher than female, the difference was statistically significant (P<0.01).8. TC,TG,HDL-C,LDL-C,gender,age and Hey regression analysis:the nalysis showed that adjusted TC, TG, HDL-C, LDL-C, gender, age, TC, TG, HDL-C and LDL-C had no effect on Hcy(P>0.05), And the influence of gender on Hey difference was statistically significant(P<0.01),compared with male, female log (Hey) average lower 0.2136μmol/L.Conclusion1.Patients with dyslipidemia in the majority with middle-aged and old group,and more women than men.2.putum Stasis Syndrome,spleen deficiency syndrome is the main TCM syndrome types of patients with dyslipidemia.3.There are some patients’dyslipidemia TCM does not meet the syndrome diagnostic criteria in patients with dyslipidemia.4. The TG level of putum Stasis Syndrome of dyslipidemia in patients is thehighest.5.Dyslipidemia in patients with putum Stasis Syndrome,spleen deficiency syndrome of Hey levels are relatively high,Hcy levels can be used as dyslipidemia in patients with an objective indicator of TCM.6. patients with dyslipidemia Hcy levels were mostly exceeded the ideal value, the combined detection of Hcy and lipid indexs in the prevention, diagnosis and treatment the atherosclerotic disease have more instructive value.7.Dyslipidemia in patients with Hcy levels in men than women. |
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