Memory Complained About Complaints And Liver Disease Syndrome 4 Years Follow-up

Backgrounds:With the aging of our population increase, socialized medicine has a heavy burden for elderly patients with chronic diseases, especially Alzheimer’s Disease (AD). Not only to increase the prevalence of age, seriously affecting the quality of life of older persons, but also to have no an effective treatment.AD is the fourth largest cause of death of adults. Early detection, early diagnosis and intervention are an opportunity. AD is currently considered to be a continuous process of change, including Mild Cognitive Impairment (MCI), its early performance is memory loss. Subjective Memory Complaint (SMC) is a clinical common complaint, but its nature is not clear, it is normal degeneration of age, predicting objective cognitive impairment, or emotional role?Objective:To investigate the properties of SMC reason, whether SMC is a harbinger of objective cognitive impairment, and it’s the relationship between SMC, depression and ganyu syndrome.Methods:Longitudinal Study. We appointed 114 people by telephone including SMC and non-SMC group of people interviewed four years ago, finally 56 people agreed to follow up. We used a series of formalized questionnaires, including Subjective Cognitive Complaints Visual Analog Scale (SCC-VAS) to evaluate the self-subjective cognitive, Mini-mental State Examination (MMSE) and Montreal cognitive Assessment (MoCA) to evaluate the objective cognitive function, Activity of daily living scale (ADL) to evaluate the activities of daily living, Hamilton depression scale-17 (HAMD-17) to evaluate of depression, homemade ganyu related symptoms questionnaire to evaluate the ganyu level. We described statistical analysis of the percentage of each group, compared analysis of differences between groups.Rseult: ① At the baseline and endpoint, in both SMC group and non SMC group, compared to original sample, follow-up population had no significant difference in sex, culture degree, past medical history, family history, life state, age, amount of each table evaluation (P> 0.05).②At the baseline and endpoint, compared to non SMC group, the score of SMC-VAS in the SCC-VAS had a significant difference in SMC group (P=0.00), but there was no difference with the score before and after to compare in each groups (P> 0.05).③At the endpoint, there was no difference between SMC group and non SMC group in the decline of objective cognitive ability. In both SMC group and non SMC group, the score of MMSE before and after to compare showed no significant difference (P> 0.05). At the baseline and endpoint, compared to non SMC group, the score of MMSE in SMC group had no significant difference (P> 0.05), and there was no difference with the score and the change distribution of each fraction before and after to compare in each groups (P> 0.05).There was the same to the score of MoCA.④In SMC group, the score of ADL before and after to compare had a significant difference (P= 0.00), but there was different from non SMC group (P> 0.05). At the baseline and endpoint, compared to non SMC group, the score of ADL in SMC group had no significant difference (P> 0.05), and there was no difference with the score before and after to compare in each groups (P> 0.05).⑤At the endpoint, there was no difference between SMC group and non SMC group in the distribution of depression (P> 0.05). In SMC group, the increased score of HAMD before and after to compare had a significant difference (P= 0.00), but there was different from non SMC group (P> 0.05). At the baseline, compared to non SMC group, the score of HAMD in SMC group had no significant difference (P> 0.05), but at the endpoint that had a difference (P= 0.047). There was no difference with the increased score before and after to compare in each groups (P> 0.05).⑥At the endpoint, there was no difference between SMC group and non SMC group in the distribution of ganyu syndrome (P> 0.05); the distribution of ganyu syndrome was a significant difference in depression (P = 0.00), but not in the decline of objective cognitive ability (P> 0.05). In both SMC group and non SMC group, the score of ganyu syndrome before and after to compare showed no significant difference (P> 0.05). At the baseline and endpoint, compared to non SMC group, the score of ganyu syndrome in SMC group had no significant difference (P> 0.05), and there was no difference with the increased score before and after to compare in each groups (P> 0.05).There was the same to the score of ganyu diagnosis.Conclusion:This study shows SMC can not predict the long-term objective cognitive ability decreased, related to study population, follow-up time and evaluation tools. SMC is closely to depression. Ganyu syndromes have been in SMC, ganyu syndrome maybe one of the pathogenesis of SMC.