Study On Association Between Polymorphism Of PTK2B Gene&Subjective Memory Complaint And Cognitive Impairment

Part Ⅰ Correlation between the polymorphism of PTK2 B gene rs28834970 SNPs and susceptibility of Alzheimer’s Disease in Chinese Han PopulationObjective A large genome-wide association study has revealed that polymorphism of genotypes in rs28834970 within PTK2 B gene is associated with Late-onset Alzheimer’s disease in Caucasians.We conducted a case-control study to investigate the correlation between the polymorphism of PTK2 B gene rs28834970 SNPs and susceptibility of Alzheimer’s Disease in Chinese Han Population.Methods A total of 172 Alzheimer’s Disease patients and 172 non-demented elderly people controls were selected.The genetic variants in PTK2B(rs28834970)was analyzed by Polymerase Chain Reaction and DNA sequencing.Results There were three kinds of genotypes in PTK2 B gene rs28834970(CC,CT and TT).However,we didn’t find a significant association(P>0.05)between PTK2 B genotypes and LOAD in Chinese Han population.The prevalence of the minor allele C in rs28834970 within PTK2 B showed no significant difference between the 2 groups in this study,either.Conclusion PTK2B(rs28834970)hasn’t been proved to be associated with susceptibility of Alzheimer’s Disease in Chinese Han population due to the sample size.Part Ⅱ Association between subjective memory complaints and cognitive impairmentAims The aim of this study was to investigate the predictive value of the source of memory complaints on the risk of cognitive impairment(CI)and cognitive decline.Methods Data on memory complaints and cognitive function were collected among 1840 Chinese participants(aged ≥55 years old)in an urban community at baseline interview and 5-year follow-up.Incident CI was identified based on education-adjusted MMSE score.Logistic regression model was used to estimate the association between the source of memory complaints and risk of CI conversion and cognitive decline,after adjusting for covariates.Results Both self-and informant-complaint was associated with increased risk of CI(OR=1.6)and cognitive decline(OR=1.3).Furthermore,this association was more significant in men(OR=2.1)for CI,OR=1.87 for cognitive decline)and in higher education level(graduation from junior high school)(OR=1.79 for CI,OR=1.4 for cognitive decline).Conclusion Both self-and informant-complaint was associated with increased risk of CI conversion and decline,especially,in persons with male gender and high educational background.