| Objective: To study the clinical efficacy of Xu-zao-geng-ping-prescription on the female climacteric hypertension patients and analyzes their Nero-immunoendocrinology index. Method: 63 female climacteric hypertension patients from Dec 2008 to Jul 2009 were collected and divided into treatment group and control group, compared with two group indexes of OBP, NPY, NT,β-EP and Sex hormones before treatment and after treatment 6 weeks. Results: (1) Compared with control group, after treatment no differences were found on OBP (P>0.05), but NPY, T, FSH, E2 were difference in two groups. In the treatment group, the level of E2 was obviously rise and its NPY, T, FSH were significantly lower than control group (both P<0.05). (2) Compared with control group, no differences were found on indexes after treatment between two group in grade 1 hypertension (both P>0.05). In the treatment group, the level ofβ-EP was increased and its NPY was obviously decreased than control group after treatment in grade 2 hypertension (both P<0.05). (3) Compared with control group, the treatment group level of E2 was increased and its FSH was decreased in pre-menopause hypertension (both P<0.05) and the levels of T, LH were lower than control group in post-menopause after treatment. (both P<0.05). Conclusion: Xu-zao-geng-ping-prescription can treat menopausal hypertension in female through raise E2,β-EP and lower NPY,T, FSH levels and disorder Nero-immunoendocrinology index may participate the patho-physiological course of menopausal hypertension in female.
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