| Objecte:To investigate the clinical effect of Bushentianjingfang treatment with premature ovarian failure. Through clinical observation, from the general efficacy, TCM syndrome efficacy, menstrual recovery and the changes of serum reproductive endocrine hormone FSH and E2, etc., they can provide scientific objective basis of effectiveness of Bushentianjingfang treatment with kidney deficiency premature ovarian failure.Methods:1. Selected 40 patients with premature ovarian failure, all cases were from July 2008 to July 2009 in Hubei Chinese medicine hospital gynecology outpatient treatment of patients with premature ovarian failure. All cases were consistent with the State Drug Administration in 2002 "issued by the guiding principles of Chinese medicine clinical research drug (Trial)" diagnostic criteria. TCM syndrome-type of kidney deficiency syndrome. By successive treatment randomly divided into treatment group and control group, treatment group 20 cases in the control group,20 cases were compared between two groups of cases by age, course of disease, Chinese medicine symptom score, pre-treatment of reproductive endocrine hormones in serum FSH and E2 levels, through the statistics inspection, there was no significant difference (P> 0.05), comparable.2. Treatment group with Bushentianjingfang, medicine:Tusizi 20g, Shudi 20g, Zishiying 15g, Sangshenzi 15g, Buguzhi 15g, Shihu 12g, Chuanduan lOg, Duzhong lOg, Chuanniuxi 8g, fertile requestor, the late menstrual period subtracts Chuanniuxi, Yin deficiency adds Huangjing lOg, Gouqizi 12g, Hanliancao 20g; Yang deficiency adds Bajitian lOg, Lujiaoshuang 20g, Xianlingpi lOg, Daily prescipition, water extracting in two oral,3 months for a course of treatment.The control group were treated with hormone replacement therapy, given artificial cycle, estrogen and progesterone therapy, oral medroxyprogesterone acetate tablets a day, 10mg, used in conjunction 5 days, stopping menstrual 3-7 days in the first 5 days or menstrual cramps menstruation is the next wave of stopping the first 7 days of oral estradiol valerate (progynova) lmg, once daily, and even served 21 days; the last 5 days plus medroxyprogesterone acetate tablets served daily 10mg,3 months, as a course of treatment. Close observation during treatment of patients with clinical symptoms, reinspection after a course of outpatient review, 3 months after drug withdrawal outpatient review or telephone follow-up, two sets of follow-up rate was 100%. During treatment were checking for safety and efficacy of observation.3.Observed changes in symptoms before and after treatment, menstrual recovery and serum reproductive endocrine hormone FSH and E2 changes.4. Statistical analysis:The data used SPSS17.0 statistical software for statistical analysis. Indicators and data based on the observed differences, all the measurement data are x±s (mean±standard deviation) that the use of t test; count data usingχ2 test.Results:1. In the integrated effect:the treatment group,20 patients recovered in 2 cases,5 cases marked effective, effective in 7 cases, 6 cases noneffective, the total effective rate was 70%, control group,20 patients recovered in 4 cases,5 cases marked effective, effective 9 cases,2 cases noneffective, the total effective rate was 90%, but the total effect compared the two groups were not significantly different (P> 0.05), shows that the integrated effects between Bushentianjingfanf and the control group are no significant difference.2. In improving the TCM syndrome areas:pre-treatment in patients with waist and knee pain, dizziness, tinnitus, night urinary frequency,malaise fatigue and other symptoms are significantly improved after treatment, the treatment group in improving the waist and knee pain, dizziness, tinnitus, night urinary frequency and malaise fatigue and other symptoms are better than the control group, there are differences (P<0.05); However, improving the sexual apathy,dull complexion and other symptoms there are no significant differences between the two groups (P> 0.05).3. in the menstrual recovery:the treatment group 20 cases, regular menstrual 4 cases, two or more times within six months of the 5cases, one times within six months of 5 cases,6 cases of amenorrhea, menstrual recovery rate is 70%; 20 patients in the control group, regular menstruation 6 cases, two or more times within six months of the 5 cases, one times within six months in 7 cases, are still the two cases of amenorrhea, menstrual recovery rate is 90%, there is no significant difference between the two groups (P>0.05).4. In serum reproductive endocrine hormones areas:the two groups of FSH are decreased after treatment, compared with pre-treatment the difference is significant (P<0.01), E2 are both increased, compared with pre-treatment the difference is significant (P<0.01), shows that the treatment group and control group are effective; the two groups after treatment, the two groups after treatment, control group FSH levels is decreased significantly compared to the treatment group, the difference is significant (P<0.01), the two groups E2 level are both increased, there are no significant difference (P>0.05).5. Detection in safe and adverse reactions:the treatment group has no adverse reactions, while the control group a small number of patients have nausea, vomiting phenomenon during treatment. There are no cases of liver and kidney dysfunction occurred.Conclusion:Bushentianjingfang can significantly improve the symptom of premature ovarian failure such as waist and knee pain, dizziness, tinnitus, night urinary frequency, malaise fatigue and so on, promote menstrual recovery, regulate the serum reproductive endocrine hormones FSH and E2 levels, no adverse reactions. They are safe and effective drugs in treatment of premature ovarian failure.
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