| Objective: To observe the effect of Wei-lian-plaster applied to the Shen-que and A-shi for patients of cancer pain on the rate of releasing cancer pain and the grade quality of life. Methods: 74 patients with different grades of cancer pain were randomly divided into the treatment group and the control group. The treatment group was treated by Wei-lian-plaster applied to the Shen-que and A-shi. Wei-lian-plaster is applied for each day;The control group was treated by Transdermal Fentanyl which is applied to the skin of the right or left clavicle which is applied for every third day; The observation period lasted six days and other druges were forbidden to control the cancer pain. During the period, We observed the site and degree of pain, KPS-mark, the patients quality of life before and after treatment, the time of drugs starting act and adverse effect. Then the data were clollected and trimmed, the statistical significance was analyzed. Results: Both the treatment group and the control group have good effects on releasing cancer pain. The total effective rate (CR+PR+MR) was 82.86% in the treatment group and 94.28% in the control group, the obvious remission rate (CR+PR) was 65.71% and 80.00%. The result showed that there wasn't statistical significant difference in total effective rate and obvious remission rate (P>0.05). The treatment group had a good effect on slight to moderate cancer pain. The total effective rate (CR+PR+MR) was 100%, 92.86% respectively. The treatment group had less effort on severe cancer pain and the total effective rate was 64.29%. The control group had a good effect on slight, moderate and severe cancer pain. The total effective rate was 100%, 92.23% and 93.33% respectively. In conclusion, the treatment group was suitable for slight and moderate cancer pain and the control group was suitable for moderate to severe cancer pain.The effect of two groups relieving pain in different position was different, the treatment group was best for the pain on internal organs and muscle and the control group was best for the pain on internal organs, muscle and nerve. However, the result showed no statistical significance (P>0.05). In the onset time of relieving cancer pain, the treatment group was (5.49±0.90) hours, the control group was (5.86±1.41) hours, the treatment group was better than the control group. However, the result showed no statistical significance (P> 0.05). The treatment group showed better effect on the improvement of QOL and satisfactory rate and KPS-mark, there was significant difference statistically between the two groups (P<0.05). The adverse effect of the treatment group was less than the control group. The result showed statistical significance. (P<0.05).Conclusion: 1) The two groups have good effects on releasing cancer pain. The result showed that Wei-lian-plaster was suitable for the treatment of slight and moderate cancer pain. The effect of treatment group relieving pain in different position was different:best for the pain on internal organs and muscle; 2) In the onset time of relieving cancer pain, the treatment group was better than the control group, the result showed no statistical significance; 3) the adverse effect of the treatment group was less than the control group. The treatment group showed better effects on the improvement of QOL and KPS-mark. In conclusion, Wei-lian-plaster's effect in treating cancer pain was obvious, It showed that external treatment with Chinese medicine had superiority in the treatment of cancer pain, especially for the patients with advanced stage cancer.
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