Clinical Observation Of Treatment Of Hyperlipemia In The Method Of Fanmuxietu

With the development of living level,hyperlipidemia tends to be more and more and harms the mankind healthiness seriously.Based on the close relationship with the atherosclerosis,it becomes an important factor in coronary heart disease (CHD),which can lead to cardiac muscle infarct and stroke.There is no doubt that hyperlipidemia is a major risk factor for mortality of cardiovascular disorders.So how to prevent and cure of it is the new focus of the medical research.The Western medicine play an important role on curing hyperlipidemia, but its side effect make itself applied definitely.The Traditional Chinese medicine (TCM)have more advantages over the earlier.The author wants to make out the effect of method of FanMuXieTu.Objective:To investigate the clinical curative effect and safety of MuShuTang in patients with hyperlipidemia though clinical trial study and give the evidence of the method of FanMuXieTu.Methods:Adopted randomization,positive medicine control method was used in this trial selected 60 suitable cases whom were parted two groups at random.Patients in trial group was treated with MuShuTang(Capillaris,Huang Qin,Zhejiang Bay,Magnolia,ground dragon,Patrina grass,Zhuru,Divine Comedy, Trichosanthes,etc.),while control group was treated with ZhiBiTuo tablet.60 days was a cause of treatment.We record the symptoms change of TCM and level of TC,TG,HDL-C,LDL-C before and after treatment meanwhile. As well,we carry on the safety observation.Treatment criterion refers to"new Chinese medicine clinical study of treatment of hyperlipidemia guiding principles"and"Evaluation of cardiovascular drugs methods of clinical research proposal"which formulated by China Cardiology Editorial Board cardiovascular medicine Measures Group.Western diagnostic criteria:In the case of a normal diet,2 weeks (new patients) in the case two times measured blood lipids in line with one of the following conditions, you can diagnosis: TC≥5.72mmol?L(220mg?dl);TG≥2.26mmol?L(200mg?dl);TG≥2.26mmol?L(200mg?dl);HDL-C≤1.04mmol?L(40mg?dl).TCM diagnostic criteria: Persons with the main card three or possess major and minor testimony of two or more(including tongue, pulse)can be diagnosed with phlegm deter-type hyperlipidemia. Main symptoms: obesity, dizziness, chest tightness, Oue, limb anesthesia; minor symptoms: heart palpitations,insomnia,mouth light,loss of appetite;Tongue and Pulse:tongue body fat,big,creamy fur;pulse slippery or muddy string stagnation.Result:1 A serum lipid levels after treatment compared two groups of patients: The trial group after treatment TC mean 5.2733±0.49327, the control group TC mean 5.2867±0.58513, P = 0.314; the trial group TG mean 2.2950±0.62045, the control group TG mean 2.2777±0.54118, P = 0.358; the trial group HDL-C mean 1.2430±0.13906, in the control group HDL-C mean 1.2577±0.14429, P = 0.507; the trial group after treatment LDL-C mean of 2.9387±0.39915, in the control group mean LDL-C 3.0157±0.42665, P = 0.643. by the two-sample t test, P values are greater than 0.05, no statistical significance, so the two groups after treatment in patients with no significant difference in blood lipid levels. according to the criterion, in the trial group : 1 cases of clinical control, 7 cases of significant effective, 18 cases of effective, 4 cases of invalid; in the control group :1 cases of clinical control,, effective in 7 cases, 18 cases of effective, 2 cases of invalid .by rank sum test, P> 0.05, the two groups have no difference in lipid treatment.2 TCM symptoms after treatment compared two groups of patients: according to the criterion, in the trial group: 2cases of clinical control, 9 cases of significant effective, 17 cases of effective, 2 cases of invalid.The total effective rate is 93.33%; in the control group: 1 cases of clinical control, effective in 8 cases, 19 cases of effective, 2 cases of invalid. The total effective rate is also 93.33%. Through rank sum test of the Clinical classification constitutes, P=0.567>0.05, no statistical significance can be seen ,so it is suggested that two groups of clinical symptoms improved after treatment in patients have no significant difference. Through rank sum test of the TCM symptom score classification, the P value all over 0.05, no statistical significance can be seen, so it is suggested that two groups of TCM symptoms improved after treatment in patients have no significant difference.3 The two groups after treatment in patients with tongue (qualitative) pulse comparison: Comparing the two groups after treatment in patients with tongue by rank sum test P=0.663>0.05; Comparing the two groups after treatment in patients with qualitative by rank sum test P=0.724>0.05; Comparing the two groups after treatment in patients with pulse by rank sum test P = 0.862>0.05; no statistical significance can be seen, so it is suggested that two groups of tongue, qualitative and pulse after treatment in patients have no significant difference.So we can see that MuShuTang can improve the patient of hyperlipidemia symptoms and decrease the lever of TC,TG and LDL-C. There are no manifest differences between the trial group and the control group.Conclusion:From what I mentioned above, it is concluded that the MuShuTang is a good prescription on treatment of hyperlipidemia patients, while the method of FanMuXieTu which conduct the MuShuTang can make an effect on hyperlipidemia. It suggests that it is worthy to studying that method deeply.