Effect Of Statin On Peripheral Blood Hematopoietic Stem Cell In Patients With Acute Ischemic Stroke

Objectiv:To study the impact of statin therapy on peripheral blood hematopoietic stem cells in patients with acute ischemic stroke,and the relationship between statin and outcome of acute ischemic stroke.Methods:28 patients with acute Ischemic Stroke were randomly divided into two groups:statin group(treated with statin,n=15),control group(not treated with statin,n=13) .Flow cytometry(FCM) was used to measure hematopoietic stem cells in peripheral blood.Enzyme-linked immunoassay (ELISA) was employed for measuring tumor necrosis factor(TNF-α)and vascular endothelial cell growth factor(VEGF) in blood serum. NIHSS was measured at admission and ten days after admission.Results: The peripheral blood hematopoietic stem cell counts gradually increased 10 days after statin treatment,the peripheral blood hematopoietic stem cell counts also increased in control group,but statin group increases more than control group(p<0.001). The concentration of VEGF on the tenth day of statin group was obviously higher than that on the first day of the same group (P<0.001). There was significant difference in the concentration of VEGF between the tenth day and the first day in control group (P=<0.001).The NIHSS significantly decreased in the tenth day both in the two groups(the P value was 0.025 and 0.049 respectively).There was no difference in NIHSS between the two groups in the tenth day(P=0.761).Conclusion: Statin therapy may increase the counts of peripheral blood hematopoietic stem cell in AIS patients.There is no effect on the tenth day's outcome with statin treated in AIS patients.