Pre-statin Treatment For Acute Ischemic Stroke Patients Treated With Mechanical Thrombectomy

Objective: To explore the safety and efficacy of pre-statin treatment for acute ischemic stroke patients(AIS)treated with mechanical thrombectomy(MT).Methods: We consecutively enrolled AIS patients treated with MT from the First Affiliated Hospital of Chengdu Medical College and Nanjing First Hospital between June 2015 to June 2019.Safety and efficacy outcomes were prospectively collected.Two groups of patients were divided by whether taking statin pre-stroke.The primary outcome was good prognosis(mRS score 0-2)at 90 days.The secondary outcome included vascular recanalization(TICI?2b),improvement of neurological impairment(24-h NIHSS score decrease ?4 points),intracerebral hemorrhage(ICH),symptomatic intracerebral hemorrhage(sICH)and death at 90 days.Univariate and multivariate logistic regressions were performed with SPSS software.Results: A total of 298 patients were included in our study.Of them,44(14.8%)patients were given statin before stroke.105(35.2%)patients with good prognosis at 90 days.254(85.2%)patients with vascular recanalization.99(33.2%)patients with improvement of neurological impairment.56(18.8%)patients with ICH,and 35(11.7%)patient swith sICH.64(21.5%)patients were died during 90 days.The primary outcome:there was no significant statistical difference of good prognosis(adjusted OR=0.93,95% CI 0.43-2.04,P=0.873)at 90 days between groups;Adjusted variables included gender,age,history of hypertension,history of diabetes,history of smoking,fasting blood glucose,admission NIHSS score,and TOAST classification.The secondary outcomes: there were no significant statistical difference of vascular recanalization(adjusted OR=0.64,95% CI 0.23-1.79,P=0.398),and of improvement of neurological impairment(adjusted OR=0.76,95% CI 0.36-1.57,P=0.461)between groups;there were also no significant statistical difference of ICH(adjusted OR=1.55,95% CI 0.61-3.89,P=0.356),of sICH(adjusted OR=1.52,95% CI 0.48-4.73,P=0.472),and of death at 90days(adjusted OR=1.671,95% CI 0.349-7.993,P=0.521)between groups.Conclusion: Pre-statin treatment may be safe in AIS patients treated with MT,but it's efficacy was not verified.