A Study On Diet And Related Factors Of Colorectal Cancer

Objective1. The aim of this study was to analyze the related factors of colorectal cancer (CRC), contains: environmental factors and the genetic susceptibility. The environmental factors include: smoking, drinking, physical exercise, mental stress, et al. The genetic factors include history of dieases and family history.So as to provide a scientific basis for the department to take preventive measures.2. We deeply researched on dietary habits and food types on the impact of colorectal cancer incidence.So as to provide a theoretical basis for the patients with preoperative and postoperative nutritional support, and for the further study of interaction between diet and gene polymorphism. This will provide a scientific basis for the"individualized"treatment of colorectal cancer.Material and Methods1. We conducted a case-control study. The case group from gastrointestinal surgical patients with colorectal cancer in a three-level hospital in Wuhan.65 cases were collected (34 cases of colon cancer, 31 cases of rectal cancer), aged 24-83 years old, 100% of the cases through pathology, surgery or endoscopic diagnosis. The control group from random survey individuals in Medical center of another three-level hospital in Wuhan, autoimmune disease, blood disease, have been suffering from malignant tumors were excluded. Close to the gender and age, we investigate a total of 233 controls.2. Using unified questionnaire to collect information, all the patients were interviewed face-to-face by interviewers.The contents include general condition, lifestyle, dietary habits and food types, history of dieases, family history, occupation, psychological factors and informed consent.3. Investigate results were entered into a database using Epidata 3.02, analysis performed using Excel and SPSS 13.0. Pearson'sχ2 test and Nonparametric Mannl-Whitney U test were used for simple factors, Unconditional Logistic Regression model for multi-factors. Calculate odds ratio (OR) with 95% confidence intervals (95%CI). P<0.05 indicated a significant difference in statistical significance.Results1. General conditionCase and control group at age, gender distribution on a better balance. Marital status, job status and educational level compared to the control group showed significant difference. Divorce or bereavement,Unemployment or retirement and highly educated people suffer from an increased risk of CRC. The difference showed statistical significance (P <0.05). Family income showed no statistical significance.2. History of diseases, familial history of cancer and CRCHistory of bloody mucus was the common risk factor of CRC. History of intestinal polyps and diabetes were the risk factors for colon cancer. Cholecystectomy was a risk factor for rectal cancer. History of family CRC was highly related with colon and rectal cancer, the OR value was 1.442 and 1.693, respectively. The difference showed statistical significance (P <0.05).3. Smoking, drinking, history of drinking green tea and CRCSmoking and Drinking showed no significance of colorectal cancer, but smoking every day count≥20 increased the risk of CRC, the difference showed statistical significance (P <0.01). Case group was 4.665 times the control group. Drinking Liquor (white alcohol) increased the risk, but showed no statistical significance. The study found the history of drinking green tea can reduce the incidence of colorectal cancer, the OR value was 0.677, but showed no significant difference (P >0.05).4. Dietary habits, Food types and CRCThose who like eating hard food increase the risk of colon cancer, the OR value was 1.131. Like eating greasy food and hot food increase the risk of rectal cancer, the OR value was 1.872 and 1.220, respectively. Pasta, cereals, milk, fruit and vegetable intake are protective factors of CRC. Pork, beef and mutton, poultry, eggs, smoked preserved meat, fried foods, animal oil intake are risk factors for CRC. Compared with the control group, the differences showed statistically significant (P <0.05). 5. Physical training and CRCThe main sports type of case group is meditation exercise, accounting for 40.0%. Moderate and strengthen training accounted for 41.6% in control group. The differences showed statistically significant (P <0.05).6. Psychological factors and CRCThe survey of mental health factors including two aspects: stress from work or family, a sense of unpleasant spirit in the past year. The results showed that these two factors in the prevalence of CRC have no statistically significant (P >0.05).ConclusionsIn this case-control study, analysis of survey data reaveals: Divorce or bereavement,Unemployment or retirement and highly educated people suffer from an increased risk of CRC; history of intestinal polyps, cholecystectomy, diabetes, bloody mucus are risk factors for CRC; those who have history of CRC increased risk. Smoking every day count≥20 increased the risk of CRC. Those preferred hard food, greasy food and hot food increasd risk. Intake meat, fried food, smoked foods, preserved meat, animal oil over the past year increased risk. Flour, cereals, milk, fruit and vegetable oil are protective factors. Less physical activity is a risk factor for colorectal cancer,there showed no statistical significance between Psychological factors and colorectal cancer. We suggest for those high-risk groups who had disese history and family history should focus on primary prevention; to guide the public choose a reasonable diet correctly, improve cooking methods, change the bad eating habits, enhance physical activity, et al. Those can prevent the occurrence of CRC effectively.