Relationship Between Levels Of Elements In Whole Blood And Colorectal Cancer Risk:A Case-control Study

Background:Colorectal cancer(CRC)is one of the most common malignant tumors in the world.It ranks the third in cancer incidence and the second in tumor-related mortality.The etiology of colorectal cancer is not clear,but some risk factors have been found,such as unhealthy lifestyle.Previous studies have investigated the role of elements in the development of colorectal cancer,but the results are inconsistent.Objective:This study was aimed at exploring relationships between elements in whole blood and colorectal cancer risk.Method:The matched case-control study included 204 colorectal cancer patients and 204 healthy controls.Basic information and blood samples were collected when subjects were recruited.Ten element concentrations(Vanadium,Manganese,Cobalt,Nickel,Arsenic,Selenium,Strontium,Molybdenum,Cadmium,Lead)in whole blood were measured by inductively coupled plasma mass spectrometry.Rank sum test was used in comparing between cases and controls.The associations between elements in blood and colorectal cancer risk were examined using conditional Logistic regression,basing on tertile distribution of each element concentration in control group.Results:Compared with controls,colorectal cancer patients had significantly higher levels of vanadium,manganese,cobalt,strontium and lead,meanwhile lower concentrations of arsenic and selenium.There were no significant difference in nickel,molybdenum,or cadmium level between case group and control group.The logistic regression results showed that adjusted odds ratio(OR)for the highest versus lowest tertile were 6.30(95%CI:1.53,25.92)for vanadium,3.44(95%CI:1.05,11.22)for strontium,3.13(95%CI:1.04,9.42)for lead,0.15(95%CI:0.04,0.54)for selenium.Manganese,cobalt or arsenic were not significantly correlated with colorectal cancer in adjusted model.Conclusions:Our study presented a significantly positive association between blood vanadium,strontium or lead level and risk of colorectal cancer,however,a significantly negative association between blood selenium level and risk of colorectal cancer.There were no significant association between blood cobalt,arsenic,manganese,nickel,molybdenum or cadmium level and risk of colorectal cancer.