Study On The Relation Between Gastric Sensory Function And Early Satiety In PBRG Patients

Objective:To evaluate the role of water load test with B-ultrasound in the proxi mal stomach dysfunction of primary bile reflux gastritis. The aims of this study w ere to transform the hypothesis of theory above to a clinical feasible test Procedur e and appraise its feasibility, safety tolerability reproducibility and reliability, and t o evaluate the gastric sensitivity of PBRG Patients and explore potential.Methods:T he gastric sensation threshold were assessed in 48 PBRG patients and 40 healthy v olunteers by water load test. The volume of water load was regarded as first satiet y threshold when subjects reported the initial perception such as epigastric filling a nd bloating during water drinking. The volume was max satiety threshold when su bjects got full satiety.Results:PBRG patients had significant lower gastric sensation threshold for both first satiety and full satiety evoked by drinking water(464±132)m 1 vs (449±15.5)m1,P>0.05.and (879±215)ml vs (1028±47.1)m1, r=0.83; respective ly)compared with normal people. There was no obvious difference of parameters in two groups of PBRG patients (372±77)ml vs (525±126)ml, p<0.05 and (700±120) ml vs (998±180)m1, p<0.05. PBRG patents had hypersensitive gastric full satiety threshold.Conclusion:The WLT may show good pragmaticibility. The significant dif ference of WLT results between HS and bile reflux gastritis patients imply that bil e re flux gastritis patients may exist proximal stomach dysfunction, and it may als o indicate the important the role of WLT with BUS in proximal stomach function.