Analysis Of Clinical Features And Total IgE Of Atopic Dermatitis In 1030 Children Of Chinese Han

Background: Atopic dermatitis is a chronic relapsing, inflammatory skin disorder affecting mostly infants and childhood. It is frequently associated with raised serum total immunoglobulin E (tIgE) levels. The link between tIgE and other clinical features of AD was obscure, especially in Chinese patients and children with AD. This study was a retrospective design of 1030 AD children in Chinese Han, and demonstrates the association between clinical features and tIgE.Object:The aim of this study was to compare the differences of clinical features between AD children with high levels of tIgE and with normal levels of tIgE in Chinese Han.Methods: The study was carried out from hospitals located in multiple cities in China. A total of 1030 pediatric AD patients less than 12 years old were enrolled in this study. The measurement of serum tIgE was carried out by the AllergyScreen Test (Mediwiss Analytic GmbH, Moers, Germany), which was performed for all the patients. Using the questionnaire in the form of collection of clinical data , then entered into a database created using software (EPI INFO, Version 6.0), and transformed to the proper format for analysis using software (SPSS, Version 10.0, SPSS Inc., Chicago, IL).Results: A total of 1030 children (634 males, 396 females) with a median age of 1.5 (0.5, 5) years were recruited this study. The median age of onset was 2 (1, 4) months. The median age at onset of disease was 3 (2, 7) months. The age of the patients ranged from 36 days to 12 years, and the age of onset ranged from 2 days to 11 years. Among the participants, 499 (48.4%) of the patients were with elevated serum tIgE, 928 (90.1%) were living in the city. Our data indicated the median age of onset in normal tIgE levels group were earlier than the high levels group (P < 0.001). The prevalence rate of'mixed'AD was significantly higher in high levels group (P < 0.001). We also found the prevalence rates of bronchial asthma (BA) and allergic rhinitis (AR) were significantly higher in AD children with high levels of tIgE than the normal levels group (P < 0.001 and P = 0.036, respectively). In contrast, no statistical significance was found for family history of atopy between the two groups (p > 0.05). The median scores of SCORAD and OSAAD were higher in the high tIgE group by Mann-Whitney test (P < 0.001 and P = 0.001). In addition, AD children with high levels of tIgE appeared to have more severe involvement (P < 0.001). Minor signs of Hanifin-Rajka diagnostic criteria, such as early age at onset (90.9%), xerosis (74.8%) and facial pallor/erythema (70.5%) were more commonly seen. It was demonstrated that the frequencies of some objective minor signs were significantly different between normal and high tIgE levels groups.Conclusions: The tIgE levels may contribute to differences of the severity and clinical manifestations of AD children, which should be a useful indicator for disease evacuation, treatment and prognosis.