| ObjectiveTo analyze the clinical characteristics and therapeutic effect of the primary headache comorbid with depression and anxiety disorders.MethodsIn outpatient clinic, 105 cases of primary headache patients were randomly selected and met the inclusion criteria,and were divided into comorbid group and non-comorbid group. All patients received corresponding treatment and 8 weeks follow-up. The Health-related quality of life was measured using the 6-item Headache Impact Test(HIT-6)and the 12-item Short-Form Health Survey (SF-12) which contained a mental health component score (MCS) and a physical health component score (PCS) ;the duration, frequency and degree of headache were recorded before treatment , 4th week and 8th week after treatment.ResultsThe Odds Ratio (OR) for depression/ anxiety disorder in the high and low headache frequency groups was 3.277, 95 percent of confidence interal(1.48,7.27). Before treatment, there were lower MCS scores (P < 0.01) and higher HIT-6 scores (P<0.01) in the comorbid group than those of non-comorbid group; after treatment, the quality of life and clinical symptoms were significantly improved in both group (P<0.01), but PCS scores increased slowly (P<0.01) and the frequency of headache attacks decreased slowly (P>0.05) in comorbid group. The percent of patients who refused to accept the follow-up or failed to complete the follow-up accounted for 31.3% in the non-comorbid group, 40.7% in comorbid group, there was no significant difference found between two groups (P = 0.318) .ConclusionThe frequency of headache episodes is closely correlated with depression / anxiety disorders in primary headache patients. Standard treatment can reduce the frequency, intensity and duration of headache, and improve the life quality of headache patients, but in the headache patients comorbid with depression / anxiety disorders the life quality become worse, clinical symptoms improved slowly and the longer courses of treatment is needed.
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