Clinical Observation Of Benazepril Combined With Bailing Capsule In Treatment Of Chronic Glomerulonephritis

Chronic golmerulonephritis, referred to as chronic nephritis, is caused by a variety of causes progressive, inflammatory immunity, primary glomerular disease. Based on proteinuria, hypertension, edema, hematuria for basic clinical manifestations, onset of different ways, protractde illness, slow progress, may have different degrees of renal dysfunction, and will eventually develop into a group of chronic renal failure glomerular disease. Due to the different pathological type and illness period of chronic nephritis, the major clinical manifestations are different, the disease present are diversified. Clinical practice by reducing proteinuria, blood pressure control and other methods to delay the progress of renal function. Has a clear impact of chronic glomerulonephritis Proteinuria is an independent risk factor for prognosis, therefore, reduce proteinuria is the treatment of chronic glomerulonephritis, worsening of renal function is one important measure. Can occur in patients with chronic high blood pressure, hypertension and kidney as main target organs, such as regulation of blood pressure if not, the patients with end-stage renal failure associated with a significantly increased risk. In the selection of antihypertensive drugs, they should try to select those clear antihypertensive effect, side effects, while for patients with heart, brain, kidney and other target organ has a protective function (such as anti-atherosclerosis, improve myocardial hypertrophy and improve vascular endothelial function of renal dysfunction, etc.) of the drug. Antihypertensive drugs can be divided into angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, calcium channel blockers,βblockers, diuretics and so on. In the treatment of chronic kidney disease, angiotensin converting enzyme inhibitors can not be ignored. Its antihypertensive effect primarily by inhibiting peripheral and tissue angiotensin converting enzyme, the decreased production of angiotensin II, but also by inhibiting kininase to reduce the degradation of bradykinin. In addition to antihypertensive effects, but its also improve vascular endothelial function, insulin resistance, but also through the expansion of the glomerular efferent arteries, lower glomerular pressure and reducing urinary protein excretion and slow renal function impairment in order to achieve renal protection role, its high level of renin renal hypertension better effect. Patients should pay attention to serum creatinine levels greater than 265umol / L, the application of angiotensin-converting enzyme inhibitors need to be cautious; hyperkalemia, pregnant women and disabled patients with bilateral renal artery stenosis. Benazepril is the 3rd generation long-acting mercapto containing ACE inhibitors, brand name Lotensin, which is characterized by two-channel discharge (via the kidneys, liver excretion) preparations, kidney damage and hypertension chronic glomerulonephritis in renal hemodynamics with good effect, because very few elderly people taking the drug accumulation time, it is particularly suitable for renal dysfunction in elderly hypertensive patients. Cordyceps species Bailing capsule is refined by low-temperature fermentation, including fermentation of Cordyceps sugar, the main component of adenosine can eliminate free radicals, reducing lipid peroxidation, improve renal blood circulation, inhibit platelet aggregation, stability of solution enzyme membrane, and promote the repair of kidney cells, reduce urinary protein excretion; other ingredients such as amino acids, mannitol, ergot alcohol and a variety of vitamins, trace elements directly involved in the metabolism, to restore nitrogen balance and promote cell injury repair and improvement has a role in immune function. The treatment of chronic glomerulonephritis of Integrative Medicine is to use more methods, this study benazepril and Bailing capsule together with the synergistic effect the treatment of chronic nephritis, can better improve symptoms, reduce urinary protein, protection of renal function.Objective To observe Clinical Effect of Benazepril combined with Bailing capsule in treatment of Chronic glomerulonephritis.Methods 52 cases of chronic nephritis patients were randomly divided into two groups: treatment group (group B) taking Benazepril combined with Bailing capsule, and the control group (group A) simply taking Benazepril respectively, two groups of testing before and after the treatment symptoms, 2 4 hours urinary protein quantitative index variation and renal function.Results The total effective group B clinical curative effect is significantly higher than that in control group (P < 0.05). Both groups can significantly reduce 24-hour urinary protein quantitative (P < 0.01), group B lower urine protein more obvious (P < 0.01).Conclusion The effect of Benazepril combined with Bailing capsule is better than that of Benazepril, it can be more significantly reducing urinary albumin excretion, with no obvious adverse reactions.