A Study Of Relationship Between Sex Hormone And Differentiations Of Women's Chloasma In TCM

Objectives:At first place, we measured the sex hormone level in blood serum of female patients suffering from chloasma and analysed the relationship between the data and syndrome types in TCM. Through all above,we built the theoretical foundation for treating chloasma by TCM methods and determining the syndrome differentiation. And, symptoms in TCM could be made objectively sustainable. Meanwhile,this study provided evidences to treatment of this disease by combination of Chinese and Western medicine. Consequently,we could be able to prevent the onset of chloasma as early as possible, make the treatment more effective, alleviate the psychological burden of patients, and improve the life quality.Methods:We collected 80 patients initially, thus only 75 ones has been used in the study, because among them,3 was eliminated and 2 was excluded owing to the eliminated and excluded criterions.According to the syndrome differentiations of chlasma in TCM,the 75 patients were divided into two types:qi stagnation and blood stasis (forty two cases) and yin deficiency of kidney and liver (thirty three cases).At the same time, we get twenty normal cases as the control group.We measured estradiol E2, follicle-stimulating hormone(FSH),luteinizing hormone(LH),progesterone P, testosterone levels of T in blood serum of them by electrochemiluminescence immunoassay, and compared the Levels of sex hormone among the three groups。Results:we measured the level of E2,LH,FSH,T,P during the sixth to eighth day in the menstrual cycle and compared them among groups.As a result, the E2 level in the group of liver and kidney yin deficiency was highest(P<0.05), indicating that Liver and kidney yin deficiency is relative to E2, and E2 could be used as sign of this type.There was no statistical significance while comparing the LH and P levels among the three groups (P>0.05); the respective testosterone T level of the two groups of patients were both lower than that of the control group, there was statistical significance (P<0.05), indicating that there was some relationship between testosterone T and the onset of chloasma; the FSH level of group of the qi stagnation and blood stasis type was higher than that of control group, there was statistical significance (P<0.05). Thus, there was no statistical significance while comparing the FSH level between the group of liver and kidney yin deficiency type and the control group and between the two groups of patients (P>0.05).Conclusions:The onset of chloasma is correlative to the unbalance of hypothalamus-pituitary-gonadal axis.E2 can be used as the sign of the type of yin defficiency of kidney and liver in chloasma.The testosterone T level of two groups of patients are lower than the control group; but there is no statistical significance while comparing it between the two groups of patients. And the LH and P levels also failed to be compared among the three groups statistically.The conclusion is able to guide the clinical practice.