The Clinical Research On The Treatment Of Renal Anemia Iron Deficiency With Strengthen Spleen And Kidney And Remove Blood Stasis And Expel Toxin Theroy

Objective:The goal of this clinical observation is to probe the clinical effect and safety of strengthen spleen and kidney and remove blood stasis and expel toxin theory in treating renal anemia iron deficiency. To provide scientific basis and more efficient and safer method in treating of renal anemia iron deficiency.Methods:60 cases of renal anemia iron deficient patients with the syndrome of deficiency both spleen Yang and kidney Yang and blood stasis. They were divided into treatment group and control group randomly in proper order, both two groups were given minimal care, at the same time we gave treatment group Sheng Xue Fang combined EPO treatment guide by the strengthen spleen and kidney and remove blood stasis and expel toxin theory, but for the control group, we gave Xue Tai combined EPO treatment, the whole treatment last two months. We measured the SF,SI,RBC,Hb,HCT,BUN,Scr before and after the treatment. The changes of accumulating grades of TCM syndrome were observed at the same time.Result:(1)In the improving of renal anemia, compared with prior treatment there was significant difference in both groups (P<0.01) after the treatment but no significant difference between the two groups post-treatment (P>0.05); (2) The SF and SI of the two groups were both markedly improved after the treatment(P< 0.001), but there was no significant difference between the two groups post-treatment; (3) In reducing the accumulating grade of TCM syndrome, there was significant difference in treatment group after the treatment (P<0.05) but not the control group (P> 0.05), there was significant difference between the two groups in the accumulating grades of TCM syndrome after the treatment(P <0.001), the treatment group was better; (4) The BUN and Scr of the treatment group was remarkably decreased after the treatment(P<0.01), but not the control group. There was significant difference between the two groups post-treatment(P< 0.05);(5)The treatment group's adverse effects were less than the other, the difference between them has statistical significance.Conclusion:The theory of strengthen spleen and kidney and remove blood stasis and expel toxin was very effective in treating renal anemia iron deficiency with the syndrome of deficiency both spleen Yang and kidney Yang and blood stasis. There was no much difference in improving the renal anemia and iron deficiency between the Sheng Xue Fang and the Xue Tai. But compare with Xue Tai, the Sheng Xue Fang had obvious advantages in curing the CRF and reducing the BUN and Scr. The Sheng Xue Fang also enjoyed distinct advantages in reducing the accumulating grade of TCM syndrome and less adverse effects.