Pregnancy-associated Plasma Protein-a Polymorphism And The Risk Of Pre-eclampsia

Objective: To estimate whether PAPP-A (Pregnancy-associated plasma protein-A) polymorphism is associated with pre-eclampsia.Methods: By means of Polymerase Chain Reaction and Single-Strand Conformation Polymorphism, S1224Y(A/C) (dbSNP: rs7020782) polymorphism in the PAPP-A gene was detected in 129 women with pre-eclampsia (64 with mild pre-eclampsia and 65 with severe pre-eclampsia)and 137 normal control women with uncomplicated pregnancy. Investigators were blinded to clinical outcomes.Results:AC genotype frequency in pre-eclampsia group were higher than those in control group(44.2 % VS 31.4 % )(P﹤0.05); AC genotype frequency in severe pre-eclampsia group were significantly higher than those in mild pre-eclampsia group (75.4%VS 12.5%) (P﹤0.01).C allele frequency in severe pre-eclampsia group were significantly higher than those in mild pre-eclampsia group (40.8%VS 18.7%)( P﹤0.01). Conclusion:The AC genotype and C allele of S1224Y(A/C) polymorphism in the PAPP-A gene might be a risk genetic marker of pre-eclampsia. In patients with pre-eclampsia, there is the association between AC genotype and C allele of PAPP-A gene and severity of pre-eclampsia.