Study Of The Relationship Of Physical And Chemical Factors Between Phlegm Turbidity Syndrome And Blood Stasis-phlegm Syndrome In AECOPD

Chronic obstructive pulmonary (COPD) is a kind of airflow limitation disease which can be prevented and cured,it is related to the not fully reversible and progressive flow imitation and the inflammatory reaction cause by harmful gus or granule from cigarette. In COPD, lung is the mainly involved organ, but other organs may also have harmful effect. COPD is the final result of various progressive lung diseases.There are no concept of COPD in Chinese traditional medicine(TCM), but according to the clinic and progress of COPD, it is similar to "cough with internal injury" in TCM. With the development of COPD, it will pertain to "gasp syndrome" and "emphyysema" in TCM, moreover, it also resemble many symptoms of TCM such as "phlegm and retained fluid" and "pulmonary flaccidity".This disease will happen in lung first, and then, influence liver and spleen, finally implicate the heart. It belongs to syndrome which is asthenia in origin of lung, spleen and kidney and sthenia in superficiality-with syndrome of intermingled phlegm and blood stasis.This study is based on the principles of the theory of TCM-symptomatic treatment in acute condition, radical treatment in chronic case. According to the symptoms of AECOPD, guide by theorys of TCM, this study investigate the differences and similarities of the physical and chemical factors between phlegm turbidity syndrome and blood stasis-phlegm syndrome of COPD through lab examination such as blood analysis, biological test, coagulation function test and blood fat test. To guide the clinical treatment, this study was carried on.Methods:300 patients with AECOPD in our hospital during Jan 2007 to Mar 2010 were brought in this study randomly. Using Retrospective study method to record datas, and then utilize statistical methods (for example:T test, analysis of variance) to investigate and analyze the datas.Result:There were 212 patients who conform to the standard. The quantity proportion of phlegm turbidity syndrome(the first syndrome) and blood stasis-phlegm syndrome (the second syndrome) had little difference. The age of onset is mainly about 50 to 80 years old, they make up 86.4% of the total quantity of patients. In these two syndromes, female patients were no more than male patients in quantity,but they had obvious difference on the condition of smoking, evidently, male patients were the main patients on these two syndrome. The course of disease of the first symdrome were nearly less than 10 years, and the second syndrome's were almost more than 10 years. And the average of hospitalization days of the first symdrome was 2and a half day less than the second symdrome's. Contrast by lab examinations, LYM% of the first symdrome is higher than the second symdrome. And the scale of RBC, HCT, PCT is obviously lower than the second symdrome(P＜0.05);on the biological test, there were no obvious diffierence. On the blood fat test, the first syndrome's scale of CHOL, LDL were obviously lower than the second syndrome's;On the coagulation function test, the scale of APTT in the first symdrome was obviously higher than the second symdrome(P<0.05).Conclusion:Physical and chemical factors between the two types of syndrome (phlegm turbidity syndrome and blood stasis-phlegm syndrome)in AECOPD were difference, the analysis and conclusion in this study is helpful for diagnosis and treatment of TCM. It is suggested that we might tell apart a patient's syndrome through the course of disease, blood analysis, blood fat test and coagulation function test.