The Effect Of Jiangzhuhuoxuefang On Carotid Artery Intimal Media Thickness And Serum Hs-CRP In Patients With Phlegm Ang Blood Stasis Syndrome Of Hyper LDL-C

Objective: In this study,the effectiveness and safety of the patients with high ldl-c and the thickening of carotid artery(IMT)were observed.Methods:Choice in January 2017 to December 2017 in the first affiliated hospital of anhui medical university of cardiovascular internal medicine outpatient or hospitalization serum LDL-C or greater tendency for 3.40 mmol/L,carotid IMT acuity 1.0mm,TCM syndrome differentiation of phlegm and blood stasis mutual junction in patients with 60 cases(all patients were made by researchers for its agreed to and signed the informed consent),were randomly divided into control group and treatment group,30 cases in treatment group given material huoxue oral medicine,the control group given: capsule(every time 2 grain,2 times/day)oral,course of 12 weeks.Other herbal preparations were avoided during the treatment.The serum ldl-c level,TG,TC,hdl-c level,IMT thickness,hs-crp content and TCM syndromes were observed before and after treatment.Results:(1)Therapeutic evaluation:(1)Layering is serum levels of LDL-C: treatment group after treatment of LDL-C higher level 9 of 11 cases of down to the right or the ideal level,2 cases dropped to edge higher levels,rising edge level 19 cases all down to the right or the ideal level;Higher level 5 out of 10 cases were down to the right or the ideal level,4 cases dropped to edge higher levels,1 case of patients after treatment is still at the higher level,rising edge level 20 cases had dropped to 18 or right ideal level,2 cases of edge is still at the higher level.In the two groups,with the rank sum test,U=219,P<0.01,there was a statistical difference,and the treatment group was better than the control group in lowering the serum ldl-c level in patients.(2)Comparison of serum LDL-C,TC,TG and HDL-C level: Compared with the treatment before treatment,LDL-C,TC and TG both decreased,and HDL-C level increased(P<0.01).Compared between the two groups,the treatment group was better than the control group in lowering ldl-c and TC(P<0.01 or P<0.05).In terms of reducing TG and elevating HDL-C level,the two groups were equally effective(P>0.05).(3)Comparison of IMT thickness: the IMT thickness of both groups was lower than that before treatment(P<0.01).After treatment between the two groups,the reduction of IMT thickness in the treatment group was better than that of the control group,with statistical difference(P<0.05).(4)Comparison of serum hs-crp level: the serum hs-crp level in both groups decreased significantly after treatment,and the difference was statistically significant(P<0.01).After treatment between the two groups,the treatment group was better than the control group,and the difference was statistically significant(P<0.05).(5)Comparison of TCM syndromes: the total effective rate of treatment group was83.33%.The control group was 63.33%;The treatment group was 20.0% higher than the control group,with statistical difference(P<0.05).(6)Efficacy of TCM syndromes and single symptoms: the efficacy of both TCM syndromes and individual symptoms improved after treatment(P<0.01 or P<0.05).Comparison between the two groups after treatment,the treatment group lower TCM syndrome score is better than that in control group(P < 0.05),the improvement of individual symptoms of traditional Chinese medicine especially in the first such as wrapped,bosom frowsty,languid,eat less,curative effect is superior to the control group(P < 0.01),in improving the heavy body,the area before the heart stabbing pain,loose stools,tastelessness,better than the control group,with statistical difference(P< 0.05).(2)Safety evaluation:The blood,urine and stool examination of 30 patients in the treatment group showed no obvious abnormal changes in the results of liver and kidney function,and no significant changes were observed in the electrocardiogram after treatment.It showed that the treatment of turbidity active blood was safer,and no obvious side effect was found.Conclusion:Material qi and reduce high blood LDL-C patients serum LDL-C,TG,TC level,improve the level of HDL-C,at the same time,can reduce the patient's carotid IMT and inflammatory factor hs-CRP levels,and improve the patients' clinical symptoms,achieve anti-inflammatory,improve endothelial function,prevention AS the function of the development.The clinical application is safe,and it is suitable for the patients with high ldl-c and patients with early AS formation.