Correlation Between Depression And Cerebral Blood Flow Velocity Changes In Patients With Subcortical Ischemic Vascular Disease

Abstract Objective To investigate the Correlation between depression and cerebral blood flow velocity (CBFV) changes in patients with subcortical ischemic vascular disease (SIVD).Methods According to the diagnostic criteria SIVD selected 57 patients, Vascular risk factors were investigated, Including hypertension, dyslipidemia, diabetes, heart disease symptoms, Drinking, smoking, cerebrovascular disease (CVD), family history of mental illness and their family history, Systolic pressure, diastolic blood pressure; electrocardiogram (ECG) whether the abnormal, Biochemical examination of serum glucose, cholesterol (CH), triglyceride (TG), etc. respectively used mini-mental state examination (MMSE), the Montreal Cognitive Assessment Scale (MoCA), Hamilton Depression Rating Scale (HAMD) scale to assess cognitive and depressive symptoms in all patients. All the 57 cases of patients with SIVD standard will be based Aharon-Peretz of leukoaraiosis (LA) is divided into four(Applied GE Signa1.5T superconductive magnetic resonance). Application of 2-MHz pulsed-wave TCD monitor (Model: GE vivid 7 Dimension) of 57 patients studied SIVD patients were under standard conditions (supine position, eyes closed, dark room) rest 5 minutes later, subjects were tested at supine bit, the first set orthotopic probe placed on the lower edge of the protrusion above the zygomatic arch (temporal window), using 2MHz pulse-probe, probing depth, respectively 50 ~ 55 mm (MCA), 60 ~ 70 mm (ACA), 60 ~ 70mmP2 section (PCA). In accordance with middle cerebral artery (MCA), anterior cerebral artery (ACA), posterior cerebral artery (PCA) of the order of 3 minutes to detect 15 connected to cardiac cycle, a record both sides of the MCA (MCA-R, MCA-L) , both sides of the ACA (ACA-R, ACA-L), and both sides of the PCA (PCA-R, PCA-L) contraction of the peak (systolic CBFV, Vs), end-diastolic flow velocity (diastolic CBFV, Vd), mean velocity (Mean CBFV, Vm), obtained as the mean statistics.All TCD detected by specially trained technicians carried out under blind.Results To HAMD score 20 as the standard will be 57 cases of SIVD patients were divided into: SIVD associated with depression group (SIVD-D, n = 27) and not associated with depression group (SIVD-ND, n = 30) were observed. there was no significant difference between SIVD-D group and SIVD-ND group in gender, age, educational level, etc. (P> 0.05). Subjects in both groups of vascular risk factors, no significant differences between the two groups of vascular risk factors showed evenly distributed. There was no significant difference between SIVD-D group and SIVD-ND group in MMSE and the MoCA total score either (P> 0.05). SIVD-D group, 2 in 14 cases, 3 in 13 cases; SIVD-ND group, 2 in 16 cases, 3 in 14 cases. Compared with SIVD-ND, SIVD-D patients showed significant decrease in CBFV, bilaterally in the middle (MCA) and the anterior cerebral artery (ACA)(p<0.05). Within SIVD-ND group, the CBFV of ACA-L and MCA-L was significantly lower than ACA-R and MCA-R (p<0.05). There was negative result in the posterior cerebral artery(PCA)(p>0.05).Conclusions Depression was widespread in patients with depressive symptoms. SIVD depressive symptoms combined presence of CBFV to reduce the MCA and ACA, and the left than the right to reduce the more prominent. Between the two groups imaging results (MRI white matter grade osteoporosis) showed no significant difference, suggesting that CBFV changes can be even earlier than the structural changes reflect SIVD depressive symptoms associated with pathological physiological changes.