The Research On Relationship Between The Serum Lipids, Osteoprotegerin And Bone Mineral Density In Postmenopausal Women

ObjectiveThe aim of this study was to investigate relationships between seurm lipids, osteoprotegerin (OPG) and bone mineral density (BMD) in postmenopausal women,probe into the mechanism of lipids disorder and bone metabolism, provide new methods for the prevention and treatment of osteoporosis.MethodsPartⅠThe 120 postmenopausal women who have taken the lumbar spine (L1-4) and femoral neck (FN) BMD test were selected according to the inclusion and exclusion criteria. Age, year of menopause, hight and weight were recorded. TC, TG, HDL, LDL were tested. According to the WHO eriterion, osteoporosis is defined as BMD more than 2.5SD below the mean of young adult women age 30-35 years old(T score≤-2.5). BMD was measured by dual enegry X-ray absorptiometry at the L1-4 and FN.In Part 1, there were 69 cases in osteoporosis group, and 51 cases in control group. T test, Pearson correlation, partial correlation and multiple linear regression were used to analysis the relationship between parameters with SPSS 16.0 software.PartⅡ80 postmenopausal women were randomly selected from the above 120 cases.There were 44 cases in osteoporosis group,and 36 cases in control group.Enzyme-linked immunoadsordent assay for serum OPG was used in all subjects. T test, Pearson correlation, partial correlation, and multiple linear regression were used to analysis the relationship between parameters with SPSS 16.0 software.ResultsPartⅠ1. The mean values of Age, YSM(years since menopause),TC,LDL were higher in osteoporosis group,and BMI,year of menopause were lower in osteoporosis group.2. L1-4 and FN BMD were positively correlated with BMI and year of menopause, negatively correlated with age, YSM, TC, TG, LDL, not correlated with HDL. Adjustment for BMI, age, year of menopause, YSM, L1-4and FN BMD were negatively correlated with TC, LDL, not correlated with TG statistically.3. In multiple linear regression model, the effect factors on L1-4 BMD were YSM and LDL (standardized partial regression coefficient were-0.465 and-0.364). The effect factors on FN BMD were YSM,LDL and BMI(standardized partial regression coefficient were-0.379,-0.326,0.319).Part II1. The mean values of YSM, TC, LDL were higher in osteoporosis group, and BMI, year of menopause and serum OPG were lower in osteoporosis group.2. OPG were positively correlated with year of menopause L1-4 and FN BMD, negatively correlated with TC, TG, LDL. Adjustment for correlated parameters, OPG were positively correlated with L1-4 and FN BMD. L1-4 and FN BMD were positively correlated with BMI and year of menopause, negatively correlated with YSM, TC, LDL, not correlated with age, TG and HDL. Adjustment for BMI, age, year of menopause and YSM, L1-4 and FN BMD were negatively correlated with TC, LDL. Adjustment for OPG, BMI, age, year of menopause and YSM, L1-4 and FN BMD were not correlated with TC,LDL statistically.3. In multiple linear regression model, The effect factors on L1-4BMD were OPG and YSM standardized partial regression coefficient were 0.452 and-0.392). The effect factors on FN BMD were OPG,BMI and YSM (standardized partial regression coefficient were 0.414, 0.334,-0.303).Conclusion1. Postmenopausal osteoporosis women have high serum TC and LDL level, which are negatively correlated with BMD.2. Postmenopausal osteoporosis women have low serum OPG level which is positively correlated with BMD and negatively correlated with TC, TG, LDL.