Research Of Vitamin D Nutritional Status And The Association Between Serum Levels Of 25-hydroxy Vitamin D And Lipids In Premenopausal, Perimenopausal And Postmenopausal Women

Objective:To describe the distribution of serum vitamin D levels in premenopausal, perimenopausal and postmenopausal women and to explore the influencing factors; to explore relationships between serum vitamin D and lipids in the subjects.Method: We performed a cross-sectional study at the medical health center of the First Affiliated Hospital of Anhui Medical University. All of the objects were healthy women over 35 years old and accepted health examination during October to November, 2014. Basic information were collected by a self-designed questionnaire survey including: general demographic characteristics, living habits, menstrual and reproductive history, previous medical history; Physical examination including: height, weight, blood pressure; clinical and biochemical indicators including: 25(OH)D, FBG, TC, TG, LDL-C, HDL-C. SPSS 16.0 software was used to conduct t test, one-way ANOVA analysis, partial correlation analysis and binary Logistic regression analysis.Results: A total of 302 cases met the criteria for the study. The mean age was 48.1 ±7.6 years. 48% of the subjects were housewives and most of them were with low level of education. 74.8% of the participants reported that their economic conditions were medium level. In this study, premenopausal, perimenopausal and postmenopausal women accounted for 35.1%, 30.5% and 34.4%, respectively. Mean serum 25(OH)D level was 15.21 ± 4.76 n /ml. Among our subjects, only 2 case(0.66%) were with sufficient vitamin D status; 44 cases(14.57%) with insufficiency vitamin D status; 256(84.77%) cases with deficiency vitamin D status.Serum 25(OH)D exhibited increasing tendency in premenopausal, perimenopausal, postmenopausal women, and the differences between them were statistically significant(P=0.013), while there is no significant difference between different groups of age, occupation, education levels, economic status were not statistically different; there is no statistically significant difference between different groups for alcohol consumption, sleep times, regular outdoor exercise and physical activity intensity; serum 25(OH)D of calcium intake group was higher than those who were not taking and the difference was statistically significant(P=0.003). However, serum 25(OH)D among different eating habits groups were not statistically different. Binary Logistic regression analysis showed that calcium intake and age were the independent factors of vitamin D.SBP, FBG, TC, LDL-C increased in turn among premenopausal, perimenopausal, postmenopausal women with statistical significance(P<0.05). Partial correlation analysis showed that serum 25(OH) D and TG were negatively correlated(r =-0.203, P= 0.045) in postmenopausal women. Serum 25(OH) D and HDL-C were negatively correlated(r =-0.274, P = 0.010) in perimenopausal women. There were no statistically significant differences in serum 25(OH)D of different lipid level groups in the total 302 cases, while there were significant differences(P=0.030) among different TG level groups in postmenopausal women by stratified analysis. Binary Logistic regression analysis showed that serum 25(OH)D was the independent factor for TG in postmenopausal women.Conclusion: Vitamin D deficiency is very common among premenopausal, perimenopausal and postmenopausal women. Age and calcium intake may affect vitamin D nutrition. There were no correlation between serum 25(OH)D and lipids among premenopausal and perimenopausal women. Low vitamin D levels may have an adverse effect on TG in postmenopausal women.