A Study On Improvement Of Joint Pain With Knee Osteoarthritis Of Damp-heat Blockage Stasis Type Treated With Gu Shi Fang

Objective To study the Therapeutic effect of Gu Shi Fang for the improvement of joint pain with Knee Osteoarthritis of damp-heat blockage stasis type.Methods According to traditional Chinese medicine classification, total 60 cases of patients with Knee Osteoarthritis of damp-heat blockage stasis type were divided into two groups at random.30 cases were treated with Gu Shi Fang in the treatment group, and the other 30 with Diclofenac Sodium Sustained Release Tablets in the control group. The following criteria were evaluated between the two groups in terms of marking system of WOMAC, C-reactiveprotein (CRP), Erythrocyte Sedimentation Rate(ESR), complications, drug safety after 2 weeks,3 weeks,4 weeks of the treatment.Results The patients of two groups were treated by 4 weeks, the overall efficiency was 93.33%, there was no obvious difference between two groups. The patients of two groups were treated by 4 weeks, The average marking system of WOMAC was 24.40±6.58 scores in the Gu Shi Fang(GSF) group and 24.17±5.56 scores in the Diclofenac Sodium Sustained Release Tablets (DSSRT) group. Statistically, there was no difference between two groups (P>0.05). The average CRP was 5.87±4.05 mg/L in the GSF group and 4.32±6.19 mg/L in the DSSRT group. Statistically, there was no difference between two groups (P>0.05). The average ESR was 19.87±12.45 mm/1h in the GSF group and 16.93±9.63 mm/1h in the DSSRT group. Statistically, there was no difference between two groups(P>0.05). Compared with two groups, between before the treatment and after 4 weeks of the treatment. In the GSF group:The average marking system of WOMAC was 41.33±12.97 scores before the treatment and 24.40±6.58 scores after 4 weeks of the treatment, after comparison, with a statistically significant difference (P<0.05);the average CRP was 17.38±25.33 mg/L before the treatment and 5.87±4.05 mg/L after 4 weeks of the treatment, after comparison, with a statistically significant difference(P<0.05); the average ESR was 37.33±31.82 mm/1h before the treatment and 19.87±12.45 mm/1h after 4 weeks of the treatment, after comparison, with a statistically significant difference(P<0.05).In the DSSRT group:The average marking system of WOMAC was 39.50±10.17 scores before the treatment and 24.17±5.56 scores after 4 weeks of the treatment, after comparison, with a statistically significant difference(P<0.05);the average CRP was 8.56±18.61 mg/L before the treatment and 4.32±6.19 mg/L after 4 weeks of the treatment, after comparison, with no statistically significance (P>0.05); the average ESR was 27.70±25.57 mm/1h before the treatment and 16.93±9.63 mm/1h after 4 weeks of the treatment, after comparison, with a statistically significant difference(P<0.05). There were 8 patients complained of abdominal pain, diarrhea, constipation, stomach, nausea, indigestion, gastrointestinal reaction, etc in the DSSRT group. Without obvious abnormalities on blood routine examination, urine routine examination, stool routine examination, liver function, renal function, electrocardiogram before and after treatment in two groups.Conclusion For the improvement of joint pain with Knee Osteoarthritis of damp-heat blockage stasis type, Gu Shi fang was effective in treatment. Statistically, there was no difference on treatment effect, marking system of WOMAC, CRP, ESR between Gu Shi fang and Diclofenac Sodium Sustained Release Tablets. But Gu Shi fang is better than Diclofenac Sodium Sustained Release Tablets on persistent therapeutic effect and complications. It's one of the ideal treatment methods for the improvement in joint pain of Knee Osteoarthritis of damp-heat blockage stasis type on conservative treatment.