| ObjectiveTo observe the efficacy of extracorporeal high frequency thermotherapy(EHFT) combining TCM Differentiation, a method can be obtained that can relieve the symptoms, improve quality of life and prolong the survival time of the old patients of advanced non-small cell lung cancer(NSCLC), so as to to provide a new and safe management for NSCLC patients.MethodsThe study adoppted a prospective, small sample and randomized controlled method and divided the elderly(≥65 years old) advanced (IIIB or IV stage) non-small cell lung cancer patients into the therapeutic regimen group(treated by TCM Differentiation therapy and EHFT) and control group(treated by TCM Differentiation therapy only) according to table of random digit; The two groups were evaluated in the disease control rate(DCR) and median survival time(MST) for the primary target and overall responce rate(ORR), time to progression(TTP) and quality of life(QOL) for the secondary target after two cycles. SPSS 13.0 will be uterlized to analyse the result in which measurement data will be analysed by t-test and numeration data by chi-square test.Results72 patients were brought in this study in all and 69 patients available are analyzed with loss of three patients.36 patients are in the control group, then 33 patients are in the combining regimen. There was little significant difference on ago, sex, pathology and stage of the disease(P>0.05). After the patients underwent different trentments, The response rate of therapeutic regimen group was 19.4%, the rate of focus stabilization was 75.0%, as the control group was9.1%,54.4%. There was significant difference according to statistical comparisons (P<0.05).As to long-term efficacy, MST of treatment group was 7.5 months, TTP was 5.5 months, and one-year survival rate were 29.9%. As far as the control group was concerned, the result was 6.0 months,4.0 months and 20.6% respectively. There was significant difference (P<0.05) on MST,TTP and one-year survival rate; EORTC QLQ-LC43 score, FACT-L score, PS score (ECOG) and TCM symptoms points were compaired respectively after the treatment, both of groups has enhanced, but the growth of therapeutic group is more significant and the difference has statistical significance (P<0.05). On the aspect of adverse effect, the incidence rates of the therapy group and control group are low.Conclusions(1) EHFT combining TCM Differentiation can get more efficacy, compaired with control group, the therapy group obtained better result on total effective rate, Lesion stability rate, etc in old patients of NSCLC.(2) The combining therapeutic regimen was better than TCM Differentiation regimen on MST, TTP and 1-year survival rate, etc.(3)The therapy group was also better than the control regimen on relieving patients'symptoms, improving quality of life.(4) The advanced non-small cell lung cancer old patients were willing to receive the combining therapeutic regimen, The efficacy was significant and It can be applied in the clinical as a new therapeutic regimen. |
