Clinical Research Of Therapy Of Huoxuetongfu To Treat Spesis

BackgroundSepsis is a common complication of serious trauma, burn, shock and surgical operations. Furthermore, it may lead to septic shock and multiple organ dysfunction syndrome if the illness getting worse. Although biotechnology and medical care have been rapidly developing, the prevalence and death rate of clinical sepsis remain high. According to statistics, every year 750,000 people suffering from severe sepsis in the United States; relevant information analysis shows that the mortality rate of acute sepsis increased from 28%to 50%or more. For the treatment of sepsis, the International Sepsis Alliance introduced the "2008 severe sepsis and septic shock treatment guidelines." it is not actually a innovative treatment but the summary or re-evaluate of the existing treatment. So to really achieve the target in the 2002 Barcelona Declaration-"in 2009 decreased 25 percent mortality rate", there still are some distance. Since the 1970s, the domestic Professor Wang Jinda and Professor Wang Baoen as the representatives of combining traditional Chinese and western medical treatment of sepsis devoted into the clinical and basic research which showed that the Chinese medical treatment of sepsis had a potential advantage. ObjectiveThis research apply TaoHeChengQi XuanfeiTongFu to treat patients with sepsis. Through observing the changes of temperature, WBC, organ function, APACHEII score, blood Coagulation and other relevant indicators, discussing the effect of Huoxuetongfu therapy treating Sepsis.Methods50 eligible patients with sepsis from Guangdong hospital of TCM were collected in accordance with established standards. According to the random principle the patients were divided into two groups, the control group received conventional Western medicine treatment. the control group accepted Chinese medicine group added Taohechengqi soup as intervention therapy on the basis of the treatment for 7 days. Each group respectively takes Acute Physiology and Chronic Health Evaluation (APACHE II) score,temperature,WBC,PLT and serum PCT quantitative test before and after treatment.This research data entry uses computer databases. The establishment and statistical analysis of the database are achieved in SPSS13.0 software packages. Measurement data uses the descriptive analysis of mean and standard deviation. The multi-group comparison measured by analysis of variance and the comparison between the two groups measured by T test (testing standardsα=0.05).ResultsThe difference of APACHE II score, PCT, temperature, PLT, blood coagulation and WBC between treatment group and control group before treating were not statistically significant(P<0.05).7 days after treatment, the treatment group APACHEII score and temperature decline in the rate compared with the control group, the difference was not statistically significant (P>0.05); the treatment group, PCT level and WBC drop by more than the control group, the difference was statistically significant (P<0.05). The index of coagulation PLT, FIB increased more than the control group, and APTT, PT drop by more than the control group, the difference was statistically significant (P<0.05). The incidence of MODS and mortality between the two groups, there was no significant difference(P<0.05).ConclusionTongfuhuoxue therapy can effectively reduce the level of PCT and WBC to reduce the extent of the infection, and improve the prognosis of septic patients. Tongfuhuoxue therapy can effectively improve the level of PLT and FIB, reduce the level of APTT and PT to improve the disorder of blood coagulation in patients with sepsis. TongfuXuanfei therapy has no significant effect to incidence of MODS and mortality in sepsis patients.