The Effect And Significance Of Salusin-α In Rat Of Pancreatitis

Objective:To explain Salusin-αwhether or not to participate in the pathogenesis of acute pancreatitisMethods:Retrograde cholangiopancreatography injection using sodium taurocholate in rats with acute hemorrhagic necrotizing pancreatitis model.TEM observation of the pancreas with small artery morphological changes in the structure of vascular.Useing serum amylase,ascites,pancreatic tissue to evaluate the histopathological changes Salusin-αin animal models of pancreatitis in the role of pre-and post-intervention.Results:Salusin-αunused animal model of intervention group,pancreatic tissue within the artery lumen surface irregularities,increased endothelial cell nucleus,mitochondrial swelling,endothelial cells protruding to the cavity increased endothelial cell cytoplasmic vesicle endocytosis and "window holes" are a marked increase Significantly, the model group shows pancreatic tissue can be seen a small number of small artery intima eNOS expression;Intervention group shows eNOS expressed significantly in small artery intima of the intervention pancreatic tissue.Vascular muscle shows less eNOS expression.Ascites volume of the treatment group,serum amylase,lipase was significantly lower than the AP group.Ascites volume of the treatment group,serum amylase,lipase were significantly lower than the AP group(P＜0.05;P＜0.01).Conclusion:Animal model of acute pancreatitis in the microcirculation Salusin-αbefore and after intervention in pathological changes in pancreatic tissue,arterial endothelial cell ultrastructure changes,changes in serum amylase,ascites confirmed the change interventions Salusin-αmicrocirculation in pancreatitis has played a certainly play apositive role.