| ObjectiveTo observe the therapeutic effects of Radix Astragali(黄芪)injection which acupoint in the point of shenshu and zusanli in curing the patients of chronic glomerulonephritis with proteinuria. And to provide a new therapeutic method to delay the development of chronic nephritis.Methods1. Sixty patients, who were hospitalized in NO. 1 hospital from Juanary in 2008 to June in 2008 and spleen-kidney QI asthenia, were chronic glomerulonephritis patients with proteinuria. They were randomly divided into the treatment group(30 cases) and the control group(30 cases) by turn. Two groups in age, gender, disease duration and a 24-hour urinary protein quantitative and renal function showed no significant difference (P> 0.05), comparable.2. The control group were mostly given the basical therapeuty, including high-quality protein, low-fat low-salt diet; Danshentong Injection (30ml adding 100ml of normal saline, intravenous drip, once per day), Jinshuibao capsules (3 times a day, each time 3 capsules) and other conventional treatment. But the patients in treatment group also received Radix Astragali(黄芪) injection which was acupointed in the either side of the point of shenshu or zusanli the other day . Both groups were treated for 20 days.3. The symptoms and signs of patients in two groups were observed before and after the treatment, including lumbago,fatigue,edama, et al. The ranked quantification chart of symptoms was filled. Therapeutic effects of two groups was compared by coping with satistic.4. The parameters of such as 24h urinary total protein (24hU-TP),Albumin,Blood urea nitrogen (BUN),serum creatinine (Scr),plasma (serum) CO2-combining power (TCO2),serum uric acid (UA), were tested and compared in two groups before and after the treatment.Results1. Comparison of clinical efficacy of two groups: treatment group contains 30 cases, the total effective rate: 83.3%; 30 cases in the control group, the total effective rate: 60%.2. Clinical symptoms of the two groups points: before treatment, the symptom score compared the two groups was not significant; after the treatment, edema,malaise fatigue,dyspepsia,alleviate symptoms, compared with the control group were statistically significant (P < 0.05).3. Urine indicators were compared: pre-treatment, two 24-hour urinary protein and fresh urine protein qualitative difference between the microscopic examination showed no significant difference (P> 0.05); after the treatment, there was a significant difference (P <0.05) . 4. The two groups of blood indicators:4.1 Renal function: pre-treatment, two groups of blood urea nitrogen, serum creatinine, serum total carbon dioxide binding rate, serum uric acid, creatinine clearance rate (Ccr) had no statistically significant difference (P> 0.05). After treatment, creatinine clearance rate (Ccr) between the two groups before and after their own control, were statistically significant (P <0.05).4.2 Albumin: There were no difference between the two groups before the treatment; And after the treatment, both statics were better , also had difference (P<0.05).5. The safety of observation: the side effects of the two groups during the treatment were not significant.Conclusion1. Radix Astragali(黄芪)injection which acupoint in the point of shenshu and zusanli can reduce chronic glomerulonephritis proteinuria Kidney Qi deficiency-type effect.2. Radix Astragali (黄芪)injection which acupoint in the point of shenshu and zusanli can release the clinical simpton such as fatigue,lumbago,edema, et al.3. Radix Astragali (黄芪) injection which acupoint in the point of shenshu and zusanli can improve the renal function with the progress in the Ccr.4. Radix Astragali (黄芪)injection which acupoint in the point of shenshu and zusanli can boost the subject of Alb.
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