Clinical Observation Of Chronic Glomerulonephritis Proteinuria Of Spleen Kidney Qi Deficiency And Blood Stasis Type Treated With Midnight-noon Ebb-flow By Acupoint Application

OBJECTIVE:To observe the curative effect and safty of midnight-noon ebb-flow, to treat proteinuria of chronic glomerulonephritis by acupoint application, and search an specific effective feasible method in treating proteinuria of CGN.METHODS:43cases in compliance with the standard for CGN were randomly divided into two groups. control group8male,13female; treatment group of10men and12women. There was no significant difference on age, sex, gender, disease duration, classify adncardinal symptoms distribution between two groups (p>0.05).The control group was treated with routine medicine and point application by Fushen’ gao at07:00-09:00, the methods was same as the treatment group; The treatment group was treated with routine medicine and point application at17:00-19:00, six hours each time, every five days. The curative courses of two group were two months.In the patching process, observed in patients with local skin redness, swelling, blisters, itching. Before and after treatment, observed the patient’s clinical symptoms, signs, liver and kidney function, electrolytes, urinalysis and other efficacy endpoints changes, recorded observation of blood, stool routine and security indicators change, fill out the clinical observation table.RESULTS:(1)The total effective rate of the treatment group was86.4%, control group the total effective rate was71.4%. there was no significant difference (p>0.05) between the treatment group and control group, which showed the treatment group had better effect than the control group in the treatment of proteinuria of CGN.(2) After treatment, the24-hour urinary protein quantitative of the treatment group compared with before, there was significant difference (p<0.05), there was no significant difference between treatment group and control group on lower24-hour urinary protein quantitative(p>0.05). which showed the treatment group had better effect on lower the24h urinary protein than the control group.(3)After treatment,both two groups all had significant differences than before at TCM clinical symptom score (p<0.05); compared with the treatment group and control groups, the TCM clinical symptom score had significant difference after treatment (p<0.05). It showed that the treatment group had better effctive than the control group in improve the TCM clinical symptom score.(4)Compared with the control groupand the treatment group, there were significant differences at improve the main symptoms of patients (p<0.05), which indicated the treatment group had better effect than the control groupp.(5) Before and after treatment, Blood, stool routine, ECG detection had no obvious abnormal changes in the three groups, before treatment, although individual items had abnormal, but after treatment, no heavier. which suggested that Fushen’gao is safe and effective, non-toxic side effects. CONCLUSION:The clinical observations showed that:The theory of midnight-noon ebb-flow had a good effect in the treatment of chronic glomerulonephritis (spleen and kidney qi deficiency type), which can improve clinical symptoms, reduce proteinuria, improve renal function, and clinical application of safe and effective, non-toxic side effects, can be used as an effective method to reduce proteinuria of chronic glomerulonephritis in the clinical application.