Observation On The Clinical Curative Effect Of The Method Of Invigorating The Kidney And Strengthening The Spleen, Clearing Dampness And Heat In Treating Chronic Glomerulonephritis And Proteinuria

Purpose: The purpose of this study is to observe the clinical effect of the therapy of chronic glomerulonephritis proteinuria by the methods of benefiting the kidney,strengthening the spleen and clearing away dampness heat.Material and Method: According to the inclusion criteria,70 patients with primary chronic glomerulonephritis were selected and randomly divided into the control group and the therapy group of 35 cases each.In the therapy,all patients were given basic Western medicine therapy,during which diet control,blood pressure reduction,lipid regulation,anticoagulation,infection prevention and so on.The control group was given Olmesartan medoxomil capsules20 mg once a day.The therapy group was given the prescription of nourishing the kidney and spleen,clearing away dampness and heat,including Cangzhu 10 g,Huangbai 10 g,Coix 10 g,Cheqianzi 10 g,Alisma 10 g,Astragalus 30 g,Baizhu 10 g,Pseudostellaria 20 g,yam 10 g,Cornus 20 g,Jinyingzi 10 g,earthworm 10 g,stiff silkworm 10 g,cicada exuviate 10 g,Euryale10g and Achyranthes 10 g,which were decocted into 300 ml with water according to 1 dose per day,and taken orally for 3 times per day.Before and after the therapy,the qualitative,quantitative,microalbumin and albumin excretion rate were observed,and the data were analyzed by Excel and SPSS 24.0.Results:1.It was found that the total effective rate of the therapy group was 85.7% and that of the control group was 65.7%,which was significantly higher than that of the control group(P =0.011).In 24-hour urinary protein quantitative therapy,there was a difference between the two groups before and after therapy(P < 0.05).There was significant difference between the therapy group and the control group after therapy,and the results were statistically significant(P = 0.016).2.In the therapy of urinary microalbumin,there were differences between the therapy group and the control group before and after therapy(P < 0.05).There was significant difference between the therapy group and the control group after therapy,and the results were statistically significant(P = 0.031).3.In the therapy of urinary albumin excretion rate(urinary albumin / random urinary creatinine),there was a significant difference between the two groups before and after therapy(P < 0.05).There was a significant difference between the therapy group and the control group after therapy,and the results were statistically significant(P = 0.016).4.In the integral therapy of TCM syndrome,there were differences in all TCM syndromes between the experimental group and the control group before and after therapy(P < 0.01).After therapy,compared with the control group,the relief degree of the experimental group was better than that of the control group(P = 0.025,0.021,0.011,0.002).Conclusions:1.Therefore,the study found that the therapy of chronic glomerulonephritis proteinuria with the method of invigorating the kidney and spleen,clearing away dampness and heat has a better clinical effect.2.The effects of Yishenjianpi and qinglishehre prescriptions on the reduction of proteinuria excretion(proteinuria qualitative,24 h proteinuria quantitative,microalbuminuria,urinary albumin excretion rate)are obvious.3.The methods of Tonifying the kidney,strengthening the spleen and clearing away dampness and heat can improve the symptoms of the patients,such as tiredness and fatigue,limb sleepiness and abdominal distension.