The Research Of Retinal Structure And Function In Children With Myopia And Myopic Amblyopia

Objective To approach the detection results of P-VEP(Pattem visual evoked potential), mfERG(Multifocal electroretinogram) and OCT(optical coherence tomography) in children with myopia and myopic amblyopia,to survey the structural and functional variance of retina in children with myopia and myopic amblyopia.Methods The P-VEP,mfERG and OCT were tested on the eyes of myopic cases(52 eyes), myopic amblyopic cases(23 eyes),post-therapy myopic amblyopic cases(23 eyes) and sound eyes of unilateral amblyopic cases(22 eyes).Results 1 P-VEP test(1) In myopic amblyopic eyes,the P100 wave amplitude densities were significantly declined and the P100 wave latencies were significantly prolonged. (2) No significant difference of P-VEP between the myopic eyes and the control eyes.(3) There were no significant differences in amplitude and latency between myopic amblyopic eyes after therapy and control eyes in the response of 8×8 checkers,while P100 wave amplitude was significantly declined and P100 wave latency was significantly prolonged in the response of 16×16 checker.2 mfERG test(1) Compare with control eyes,the P1 wave amplitude densities in one to six rings of mfERG first order kernel in myopic amblyopic eyes and myopic amblyopic eyes after therapy were significantly attenuated,but there were no significant differences in P1 wave latencies.(2) There were no significant differences in P1 wave amplitude densities and latencies between myopic eyes and control eyes.3 OCT test(1) Compared with control eyes,the retinal nerve fiber layer(RNFL) thickness in inferior quadrant and the average thickness of the peripapillary RNFL were significantly thinner in myopic amblyopic eyes and myopic amblyopic eyes after therapy,while there were no significant differences of the RNFL thicknesses in superior,nasal and temporal and the thickness of fovea.(2) The thicknesses of RNFL in temporal and the fovea were significantly thicker in moderate and severe myopic eyes.But no significant differences of the RNFL thickness were found in superior,nasal and inferior.Conclusions(1) The myopia does not affect the transmission of visual perception and the function of outer retina,but can change the structure of retina.(2) there are significant abnormalities in the transmission of visual perception,the function and structure of retina in the eyes with myopic amblyopia.This situation still exists in the eyes with myopic amblyopia after therapy.