| Objective:The purpose of this study from the clinical observation of addition and subtraction together JWSNS superficial treatment of chronic antral inflammation(Spleen and Stomach Damp-Heat) and to explore the effect of the possible mechanism of its clinical research and provide a theoretical basis of new drugs.Research Methods(1) Chinese medicine hospital in Hubei Province selected medical out-patient treatment to digest and 60 cases of patients(by gastroscopy and pathological examination,diagnosed as chronic superficial antral Yan,Chinese for the Spleen and Stomach Damp-Heat Syndrome),were randomly divided into treatment group(combination of western medicine group) and the control group(simple western medicine group) 30 cases each.The two groups before treatment in patients with sex,age,course of disease,the main symptom of Chinese medicine,Chinese medicine symptom score,risk factors(diet, emotions,excessive work and rest,Six,tobacco,etc.) gastroscopy,the pathological examination,etc.,comparisons were not significantly different (P> 0.05),comparable.(2) asked in detail about the history of trigger factors in order to discover and seek to eliminate,with the psychological counseling of patients with abnormal mood to slow down.Combined treatment group JWSNS addition and subtraction(Rhizoma 10g,Honokiol 10g,Chenpi 10g,Radix 10g,bitter orange 10g,Radix Paeoniae Alba 10 g,Fanxia 10g,Xuan Hu 10g,yi ren 20g, Poria cloud 15g,Atractylodes macrocephala 15g,Zhigancao 6g etc.) treatment, served warm decoction a day,taking a two,200ml / times at the same time give the basis of clinical symptoms in patients with different types of Western medicine:the anti-acid has given esomeprazole triazole magnesium enteric-coated tablets(letter-resistant,oral,40mg / times,1 times / day) acid, there is delayed gastric emptying and duodenal juice reflux given itopride hydrochloride tablets(Swiss-phenanthroline complex oral,50mg / time,3 times / day) prokinetic,has gastric hyperemia,given the serious erosion hydrotalcite film(Granville to the United States,oral,20mg / time,3 times / day) to protect gastric mucosa,HP-positive cases at the same time give Clarithromycin sustained-release tablets,oral,250mg / times,2 times / day), amoxicillin capsules strong,oral,1.0g / times,2 times / day),pantoprazole capsules(Pan-li Su,oral,40mg / times,2 times / day),the control group according to symptoms and HP infection in the treatment group given the same treatment in western medicine alone.(3) two cases are around for one course of treatment,medication after one course of treatment to determine efficacy.After treatment were observed in patients with clinical efficacy,the main points of TCM symptoms and improve the situation,endoscopy examination,pathological examination of Hp negative and tongue,tongue to improve the situation.(4) statistical analysis methods:statistical software SPSS12.0 data for analysis.Information on the use of Level Ridit analysis,count data using X2 test,measurement data using t test.Results: 1.Treated the overall clinical efficacy of the treatment group was 93.3%, 76.7%for the control group,with statistical analysis,P <0.05,significant difference.2.The treatment group in the efficacy of traditional Chinese medicine symptom total effective rate was 93.3%,76.7%for the control group,with statistical analysis P <0.05,significant difference;treatment group symptom points of Chinese medicine,Chinese medicine master,sub-points to improve in both cases better than the control group(P <0.05).3.Mirroring the treatment group at the stomach,there is the pathological changes in the efficiency are as foll0ws:90.0%,88.3%,respectively,the control group:73.3%,66.7%,the treatment group improvements in these areas are better than the control group(P < 0.05)4.Tongue tongue improvement in the treatment group than the control group(P <0.05).5.The two groups of Hp infection did not significantly improve.ConclusionSimple use of western medicine in the treatment of chronic superficial antral inflammation(damp-heat in spleen and stomach) at the same time add decoction of Chinese medicine combined treatment JWSNS increase of about plus or minus 15 percentage points,the mechanism may be related to the following aspects:(1) the protection of gastric acid suppression,reduced injury factor in the attack:the main means of Chinese medicine is to improve.gastric mucosal perfusion cycle,an increase of gastric mucosal prostaglandin synthesis, enhanced gastric mucosal barrier,the protection of gastric mucosa from acid attack.Fangzhong Honokiol in Magnolol can inhibit gastric acid secretion, also has preventive and therapeutic effects of gastric ulcer,cloud Baishu to enhance the role of gastric mucosal barrier,and accelerate the healing of inflammation.And the alkaloid berberine has a protective effect on the gastric mucosa,the possible role of inhibition of gastric acid secretion,enhance mucosal barrier function and improve blood Supply to gastric mucosa, regulation of autonomic nervous system function,inhibit the generation of proinflammatory factors,such as peroxide.Cangzhu to experimental anti-gastritis and gastric ulcer,and the other gastrointestinal movement of the adjustment.(2) increase in gastric peristalsis,and promote gastric emptying may be related to gastrointestinal motility dysfunction,gastrointestinal disorders regulating motor function,slow down the peristalsis of the stomach.Chaihu, Aurantii together and sub-fry pan-fried combination,can significantly enhance gastric emptying,regulation of gastrointestinal motor function has two-way role,its role in the adjustment of gastrointestinal motility and atropine, respectively,and similar to those of cisapride.And medicine Jianpi Yiqi Ling-yun,Atractylodes macrocephala and so on,common in the digestive tract to adjust its role in sports.(3) adjustment disorder of neuroendocrine function:Long-term anxiety, depression and other disorders of autonomic nervous cause,thus giving rise to abnormal emotional,State Department of digestive diseases reported in the literature 50%from "heart disease" caused by,that is,emotional and spiritual, and traditional Chinese medicine consider Liver Shu is not emotional depression,with medicine Chaihu Shugan Qi,Cyperus Jieyu liver,etc.,with calm and soothe the nerves,such as a wide range of central inhibition.In addition to the prescription of Banxia,Huanglian,pale surgery,such as drugs, or damage through the direct inhibition of tumor cells,tumor-induced apoptosis,the impact of its nucleic acid metabolism and activation of the immune mechanism such as to exert its anti-tumor effect can be blocked the disease progresses,the cancer to reduce the rate of CSG Related to the treatment of the disease combined with Western medicine,the synergistic enhanced effect.Description Modified Sini's group to meet the clinical reality,in the treatment of chronic superficial gastritis(Spleen and Stomach Damp-Heat) does have a certain effect,it is worth further research and promotion.
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